abs810002 SB 203580；152121-47-6
| 參考價(jià) | ￥331.00-￥1682.00 |
- 公司名稱 愛(ài)必信（上海）生物科技有限公司
- 品牌absin
- 型號(hào)abs810002
- 所在地上海市
- 廠商性質(zhì)生產(chǎn)廠家
- 更新時(shí)間2024/10/24 11:23:21
- 訪問(wèn)次數(shù) 1383
| 5mg | 331.00元 | 999 件可售 |
| 10mg | 403.00元 | 999 件可售 |
| 100mg | 1682.00元 | 999 件可售 |
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生化試劑，分子生物學(xué)試劑，血清，細(xì)胞培養(yǎng)試劑，化學(xué)試劑，免疫學(xué)試劑，耗材，儀器，定制服務(wù)
| CAS | 152121-47-6 | 純度 | ＞98% |
|---|---|---|---|
| 分子量 | 377.44 | 分子式 | C21H16FN3OS |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 5mg;10mg;100mg |
| 貨號(hào) | abs810002 | 應(yīng)用領(lǐng)域 | 生物產(chǎn)業(yè),綜合 |
| 主要用途 | - |
產(chǎn)品描述：
SB203580是一種p38 MAPK抑制劑，在THP-1細(xì)胞中IC50為0.3-0.5μM，對(duì)SAPK3(106T)和SAPK4(106T)選擇性低10倍，且阻斷PKB磷酸化，IC50為3-5μM。SB203580是第一個(gè)被報(bào)道的p38抑制劑。
保存方法：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
別名：
Adezmapimod；RWJ 64809
外觀：
white to off-white powder
可溶性/溶解性：
DMSO：43 mg/mL (113.92 mM)
靶點(diǎn)：
p38 MAPK；PKB
In vitro(體外研究)：
SB203580 inhibits the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC50 of 3–5 μm. SB203580 also inhibits IL-2-induced p70S6 kinase activation, although the concentration required is slightly higher with an IC50 above 10 μm. SB203580 also inhibits the activity of PDK1 in a dose-dependent manner with an IC50 in the 3–10 μm range. SB203580 inhibits p38-MAPK stimulation of MAPKAPK2 with an IC50 of approximately 0.07 μM, whereas inhibits total SAPK/JNK activity with an IC50 of 3–10 μM. SB203580 at higher concentrations activates the ERK pathway, which subsequently enhances NF-κB transcriptional activity. SB203580 induces autophagy in human hepatocellular carcinoma (HCC) cells.
In vivo(體內(nèi)研究)：
SB203580 protects pig myocardium against ischemic injury in an in vivo model. SB203580 is effective to prevent and treat the disease in MRL/lpr mice model of Systemic lupus erythematosus (SLE).
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