CHIR-99021 trihydrochloride（2mg）
| 參考價(jià) | ￥ 600 |
| 訂貨量 | ≥1 |
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- 公司名稱 愛必信（上海）生物科技有限公司
- 品牌 absin
- 型號
- 產(chǎn)地
- 廠商性質(zhì) 生產(chǎn)廠家
- 更新時(shí)間 2024/7/7 19:19:08
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| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 2mg |
|---|---|---|---|
| 貨號 | abs818359 |
| 概述 | |
|---|---|
| 描述 | CHIR-99021 trihydrochloride is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. |
| 性能 | |
|---|---|
| 純度 | ＞98% |
| 分子量 | 574.72 |
| 化學(xué)式 | C??H??Cl?N? |
| 分子結(jié)構(gòu)式 |  |
| 溶解性 | DMSO: ≥ 32 mg/mL |
| CAS號 | 1782235-14-6 |
| 參考文獻(xiàn) | |
|---|---|
| [1]. Ring DB et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95. [2]. Weikel KA et al. Knockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells. Biosci Rep. 2016 Sep 16;36(5). [3]. Ai Z et al. CHIR99021 enhances Klf4 Expression through β-Catenin Signaling and miR-7a Regulation in J1 Mouse Embryonic Stem Cells. PLoS One. 2016 Mar 3;11(3) [4]. Preston GC et al. Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes. EMBO J. 2015 Aug 4;34(15):2008-24. [5]. Preston GC et al. Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes. EMBO J. 2015 Aug 4;34(15):2008-24. | |
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