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          Imgenex公司表觀遺傳學研究工具:Dnmt與HDAC抗體

          點擊次數(shù):4104 發(fā)布時間:2011-10-5

          Imgenex公司表觀遺傳學研究工具:Dnmt與HDAC抗體
           
          Dnmt and HDAC Antibodies for Epigenetics
          Cell Regulation & DNA Repair
           
          Histonedeacetylases exert transciptional control through deacetylation of core histone proteins. DNA methyltransferases regulate gene expression through cytosine methylation –changes in methylation patterns have been linked with neoplasia development. As a recognized leader and tool provider for cell regulatory pathway analysis, IMGENEX provides a comprehensive choice of highly referenced, validated antibodies specific for HDACs and Dnmts. We are continuing to build upon our leading portfolio for studying cell regulation by introduction of new products including transcription factors, ChIP Kits, signaling molecules and other key biomarkers. Utilization of our Pathway Profiling expertise and products continues to enable advanced research in Cancer, Apoptosis, Stem Cell/Developmental Biology and Immune/Inflammation Signaling Pathways.
           
          Applications:
          •  Western Blot
          •  IHC
          •  ChIP
          •  Flow Cytometry
           
           
          HDAC Antibodies
          HDAC-1 HDAC-6
          HDAC-2 (Ab-394) HDAC-7
          HDAC-3 HDAC-7 (Ser155)
          HDAC-4 HDAC-7 (Ser318)
          HDAC-4 (Ab-632) HDAC-7 (Ser448)
          HDAC-4 (Ser632) HDAC-8 (Ab-39)
          HDAC-5 HDAC-8 (Ser39)
          HDAC-5 (Ab-498) HDAC-9
          HDAC-5 (Ser498)  
           
          Dnmt Antibodies
          Dnmt1 Dnmt3a
          Dnmt2 Dnmt3b
           
          Related Pathways
          Transcription Factors
          Apoptosis Detection Kits/pSIVA
          NF-kB Pathway
           
          Dnmt3a, IMG-268A
          Expression of Dnmt3a in the nuclei of post-mitotic neurons in the olfactory epithelium (OE). DNMT3a (red) is co-expressed with neuron-specific tubulin (green) throughout the development of the olfactory epithelium, using IMG-268A. (Data courtesy of A. Jane Roskams, University of British Columbia).
           
          HDAC-7 (Ser155), IMG-612
          Western blot analysis of phosphorylated HDAC-7 in (A) recombinant fusion protein containin a phosphorylated serine at position 155 and (B) fusion protein containing an unphosphorylated serine at position 155, using IMG-612 at 0.1 ug/ml.

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