3D器官模擬芯片,HUMIMIC Chip 2/3/4-現(xiàn)貨,HUMIMIC Chip2,HUMIMIC Chip3, HUMIMIC  chip4

授權(quán)代理，現(xiàn)貨供應(yīng)，

類器官模擬

3D微流體類器官模擬系統(tǒng)，2009年起擔(dān)任人體器官芯片系統(tǒng)及微流體專家 。我們的使命: 提高對藥物 安全性 & 有效性 的預(yù)測通過器官芯片 (MOC) 檢測.
主要用途：細(xì)胞組織毒理學(xué)測試，生物標(biāo)記發(fā)現(xiàn)、神經(jīng)，免疫，代謝系統(tǒng)靶向藥物研發(fā)、癌癥個人化藥物開發(fā)、早期臨床藥代動力學(xué)數(shù)據(jù)提供，體外活體組織培養(yǎng)等。
產(chǎn)品特點：

1.SEED種植

•任何細(xì)胞都能輕松的種植在開放式的培養(yǎng)板上。
 •廣泛的培養(yǎng)形式選擇，包括商業(yè)植入物，器官切片，3D基質(zhì)和凝膠，組織特異性支架，無支架培養(yǎng)
   •容易定制或驗證細(xì)胞/組織模型的加載系統(tǒng)包括MucilAir™,EpiSkin™和更多其他系統(tǒng)
2.CULTURE培養(yǎng)

•可編程應(yīng)用流體學(xué)。器官內(nèi)流量可調(diào)，優(yōu)化氧氣，營養(yǎng)和機(jī)械力

 •可方便地優(yōu)化各器官間的流速，以實現(xiàn)的平臺藥動學(xué) •媒介變化迅速且容易實現(xiàn)

3.DOSE給藥 

•介入生物制劑(肽、蛋白質(zhì))、小分子、激素等

•基因編輯(CRISPR, Talen, ZFN)
               •引入免疫細(xì)胞(如細(xì)胞毒性T細(xì)胞、CAR-T細(xì)胞、NK細(xì)胞等)進(jìn)行免疫分析和觀察 
               •無PDMS組件，大限度減少非特定綁定干擾

  4.ANALYZE 分析 

•簡單的(重復(fù)的)介質(zhì)取樣用于生物標(biāo)志物分析(LC-MS, ELISA, multiplex)
            •可移動支架允許對微組織進(jìn)行quan方位的分析組學(xué)方法
             •組織模擬可用于成像，以可視化細(xì)胞形態(tài)、細(xì)胞遷移和蛋白標(biāo)記物定位
應(yīng)用領(lǐng)域：

生物工程學(xué)與3D細(xì)胞培養(yǎng)

動物實驗替代方案

神經(jīng)，代謝系統(tǒng)靶向藥物研發(fā)

個人化藥物研發(fā)

在培養(yǎng)皿中臨床試驗

藥物，煙草，化妝品，化學(xué)行業(yè)監(jiān)管測試免疫

HUMIMIC Chips – Superpowers for Superb Insights

The success of any mission depends on having the right equipment. We offer chips that are perfectly tailored to your needs and your HUMIMIC Control Units. The choice of tissue source is yours: Regardless of whether you are using cell lines, primary cells, biopsies, tissue sections, or commercially available models, HUMIMIC chips provide a reliable platform for all your experiments. Interested in working with iPSCs? You can conveniently combine HUMIMIC iPSCs with HUMIMIC chips.

HUMIMIC Chip2

HUMIMIC Chip2

The HUMIMC Chip2 allows the simultaneous culture of two different organ models. Cells and tissues can be used to emulate biological barriers like the intestine, lung or skin, as well as to grow spheroidal and matrix-supported cultures for mimicking the three-dimensional environment of organs like the liver.

Product description

The organ models are connected by microfluidic channels. An on-chip pump enables a near lifelike nutrient and oxygen supply to the cells. This allows for detailed studies of distribution and metabolization of various substances like drugs, cosmetics, chemicals, and food additives enabling the prediction of substance effects.The HUMIMIC Chip2 is designed for use with non-invasive in-process controls like fluorescence microscopy and other optical methods .

A control unit like the HUMIMIC Starter is necessary to operate the HUMIMIC Chip2.

Features

• Efficient lifelike tissue nutrition
• Flexible combination of different tissues
• Compatible with different types of cell culture (primary cells, iPS-based models, biopsies)
• Long-term performance
• Physiological shear stress applicable
• Rapid prototyping for specific customer needs

HUMIMIC Chip3

HUMIMIC Chip3 und HUMIMIC Chip3plus

The HUMIMIC Chip3 is designed for the simultaneous c*tion of up to three organ models in a common microfluidic circuit. The HUMIMIC Chip3 und HUMIMIC Chip3plus have all the advantages as the HUMIMIC Chip2 while allowing the culture of an additional organ model.

Product description

The HUMIMIC Chip3 and Chip3plus gives you additional flexibility when selection your cell cultures due to its tailored design approach featuring organ compartments of varying size. A control unit like the HUMIMIC Starter is necessary to operate the HUMIMIC Chip3.

Features

• Efficient, lifelike nutrition of up to three organ models
• Flexible combination of different tissues
• Compatible with different types of cell cultures (primary cells, iPS-based models, biopsies)
• Long-term performance
• Physiological shear stress applicable
• Rapid prototyping for specific customer needs

HUMIMIC Chip4

HUMIMIC Chip4

The HUMIMIC Chip 4 enables easy integration of up to four different organ models, e. g. a combination of intestine, liver, kidney and neuronal tissue in one system.

Product description

The PBPK-compliant design allows for quantitative in vitro to in vivo extrapolation. The HUMIMIC Chip 4 uses two separate microfluidic circuits to model processes like excretion and reabsorption of various substances in the kidney model.

Features

• Efficient, lifelike tissue nutrition of up to four organ models
• Supports relevant PK/PD modeling for quantitative in vitro to in vivo extrapolation and determination of ADME profiles (absorption, distribution, metabolism and excretion)
• Long-term repeated performance
• Physiological shear stress applicable
• Enables multi-organ disease modelling

HUMIMIC Chip XX/XY

HUMIMIC ChipXX /ChipXY

HUMIMIC ChipXX and HUMIMIC ChipXY will be our most potent products among our Multi-Organ-Chips. They will reproduce a systemic model of the female and male body, respectively. HUMIMIC ChipXX und HUMIMIC ChipXY have the power to model human physiology thereby generating highly predictive data sets. (In Development)

Product description

Establishing personalized disease models on these Chips will ultimately lead to a “Patient-on-a-Chip”. Drugs can be tested on this chip before being administered to patients in order to gain information about efficacy and side effects. Thus, HUMIMIC XX and HUMIMC XY pave the way to personalized medicine approaches.

Features

• “Patient-on-a-Chip” system with high physiological relevance
• Will be able to generate data previously only accessible through clinical trials (phase I and II)
• Will reduce animal testing on a large scale