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          AIRWAY LUNG-CHIP肺芯片現(xiàn)貨現(xiàn)貨,ALVEOLUS LUNG-CHIP現(xiàn)貨

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          AIRWAY LUNG-CHIP肺芯片現(xiàn)貨現(xiàn)貨,ALVEOLUS LUNG-CHIP現(xiàn)貨

           

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          Model Overview

          Due to the distinct structure and biology of different parts of the lung and their differentiated role in disease processes, we are developing a range of Lung-Chips to enable human-relevant research related to lung diseases and various aspects of lung biology.

          Alveolus Lung-Chip

          The Alveolus Lung-Chip emulates fundamental lung functions of the alveolus, such as gas exchange and absorption. It has been used in a range of applications, including evaluation of nanoparticle absorption and toxicity, study of disease development, and assessment of adverse drug effects, such as pulmonary edema and pulmonary thrombosis.

          Lung-Chip

           Neutrophil recruitment in response to bacterial infection in the Lung-Chip

          Copy of Lung-Chip Diagram

           Immune cells (blue) engulfing bacteria (yellow) in the Lung-Chip

          Lung-Chip

          Airway Lung-Chip

          The Airway Lung-Chip recapitulates the physiology and function of the airway epithelium, which conducts inhaled air to the alveolar air sacs. Research done by our scientists and with our collaborators has demonstrated that the Airway Lung-Chip models inflammation and therapeutic responses that are typical of human small airway diseases, including asthma and chronic obstructive pulmonary disease (COPD).

           Sendai viral infection recreated in the Airway Lung-Chip

          Sendai viral infection recreated in the Airway Lung-Chip

           SEM image of ciliated cells in the Airway Lung-Chip

           Ciliated cells in the Airway Lung-Chip perform mucociliary clearance, like they do in the body

           Ciliated cells in the Airway Lung-Chip perform mucociliary clearance, like they do in the body

          Resources

           

          PUBLICATIONS

          Organs-on-chips with integrated electrodes for trans-epithelial electrical resistance (TEER) measurements of human epithelial barrier function

          May 26, 2017

          A Primary Human Lung Alveolus-on-a-Chip Model of Intravascular Thrombosis For Assessment of Therapeutics

          May 17, 2017

          Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip

          Nov 23, 2016

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