基底膜剛度細胞牽張培育裝置系統(tǒng)，基底膜彈性可調(diào)細胞牽張拉伸動態(tài)培養(yǎng)或靜態(tài)培養(yǎng)（1-180kpa）,適合原代和干細胞牽張拉伸培養(yǎng)，BioFlex CellSoft培養(yǎng)板是當今wei一可在商業(yè)上可行的可施加細胞拉伸負荷的柔軟表面

基底膜剛度細胞牽張培育裝置系統(tǒng)，基底膜彈性可調(diào)細胞牽張拉伸動態(tài)培養(yǎng)或靜態(tài)培養(yǎng)（1-180kpa）,適合原代和干細胞牽張拉伸培養(yǎng)，BioFlex CellSoft培養(yǎng)板是當今wei一可在商業(yè)上可行的可施加細胞拉伸負荷的柔軟表面。

美國Flexcell細胞應力加載培養(yǎng)與實時觀察分析系統(tǒng)，包括：
1.1.FX-5000T體外細胞拉應力加載培養(yǎng)與實時觀察分析系統(tǒng)
1.2.FX-5000C細胞組織壓應力加載培養(yǎng)與實時觀察分析系統(tǒng)
1.3.FX-5000TT細胞組織三維拉應力加載培養(yǎng)與實時觀察分析系統(tǒng)
1.4.STR-4000流體剪切應力加載培養(yǎng)與實時觀察分析系統(tǒng)。

其產(chǎn)品成熟度高、成功應用文獻量達4000多篇，國內(nèi)有包括上海交通大學、復旦大學、同濟大學、上海第九醫(yī)院、中科院力學所、北京大學第三醫(yī)院、北航生物與醫(yī)學工程學院、都醫(yī)科大學、廣州醫(yī)科大學、南方科技大學、福建協(xié)和醫(yī)院、南方醫(yī)科大學近100家成功高校、醫(yī)院及基礎科研單位使用，無技術風險和使用風險，flexcell體外高通量細胞牽張拉伸力、壓應力以及流體剪切力加載培養(yǎng)系統(tǒng)已成為細胞力學體外加載模型的黃金標準，是細胞組織力學研究者的shou選。

 

CellSoft™ Soft Substrate References

Key References:

Buxboim et al., How deeply do cells feel:methods for thin gels. J Phys Condens matter. 22: 1-19, 2010.

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Chodhury et al., Soft substrates promote homogeneous self-renewal of embryonic stem cells via down regulating cell-matrix tractions. PLOS 1 5: 1-10, 2010.

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Engle et al., Matrix elasticity directs stem cell lineage specification. Cell 126: 677-689, 2006.

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Hirata and Yamaoka. Effect of stem cell niche elasticity/ECM protein on the self-beating cardiomyocyte differentiation of iPS cells at different stages. Acta Biomat. 65: 44-52, 2018

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Megone et al., Impact of surface adhesion and sample heterogeneity on the multiscale mechanical characterization of soft biomaterials. Sci Rep 8: 6780, 2018.

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Ou et al., Visualizing mechanical modulation of nanoscale organization of cell-matrix adhesions. Integr. Biol. 8: 795-804,2016.

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Palchesko et al., Development of polydimethylsiloxane substrates with tunable elastic modulus to study cell mechanobiology in muscle and nerve. PLOS 1 7: 1-13, 2012

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Smith et al., Mechanosensing of matrix by stem cells: from matrix heterogeneity, contractility and the nucleus in pore-migration to cardiogenesis and muscle stem cells in vivo. Sem Cell Devtbio. 71: 84-98, 2017

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Solon et al., Fibroblast adaptation andstiffness matching to soft elastic substrates. Biophys J. 93: 4453-4461, 2007.

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Thomas et al., Measuring the mechanical properties of living cells using atomic force microscopy. J Visual Exp. 76:1-8, 2013.

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Vertelov et al., Rigidity of silicone substrates controls cell spreading and stem cell differentiation. Sci Rep. 6:1-10, 2016.