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詳細介紹
細胞細菌實時表型反應測量系統(tǒng)
細胞代謝和監(jiān)測變得容易，我們的無標記多通道測定法以非凡的度實時測量細胞和病原體的特定代謝表型。
使用微量量熱法實時監(jiān)測生物膜代謝。
快速抗菌藥敏測試
對抗生素功效的一次或多次測試的細菌反應的高靈敏度測量–監(jiān)測生死的準確性和速度達到新水平。
- 實時直接代謝讀數，無需標記或添加
- 表型反應可提供易感和耐藥菌株的確切行為
- 快速檢測時間可快速診斷
- 連續(xù)和定量可視化的殺菌和抑菌效果
- AST的多功能抗生素組合測試
Thermogram
calScreener™ raw data
Heat over time curve
Integrated data, equivalent to bacterial growth curve
Escherichia coli planktonic growth in Mueller Hinton media. Normalized data vs control.
calScreener measures the power produced from the sample in Joules per second or µW and gives a specific curve dependent on the specimen and the culture media. When calScreener data is integrated over time the heat over time curve matches the conventional density growth curves from which the growth parameters can be calculated. Parameters such as maximum growth rate (the slope of the log phase in h-1) and the total biomass of the culture (Peak power in µW).
我們地測量生與死
直接代謝讀數–我們通過監(jiān)測暴露于抗生素的細菌的代謝變化來衡量生命的特征，calScreener™是wei一可以做到這一點并提供生長動力學和長期細胞生存力讀數的解決方案
定義有效的組合治療
現有數量有限的抗菌劑，并且尚無用于組合療法測試的商業(yè)解決方案。 我們將為組合測試設定新的金標準
高靈敏度-提供準確的數據
calScreener具有很高的靈敏度，并且可以連續(xù)監(jiān)測暴露于抗生素的細菌的代謝反應
快速實時的響應
不到8小時的抗生素敏感性以及正確測量細胞對細菌的殺傷和抑制作用意味著沒有因細胞碎片或裂解細胞引起的錯誤反應
P. aeruginosa
A. baumannii
P. aeruginosa and A. baumannii planktonic growth in Mueller Hinton media, same experimental conditions as for BMD.
The calScreener™ gives completely flexibility regarding the single or combo treatment, making AST most flexible and relevant.
In these graphs, it can be observed the lack of effect in the metabolism of the culture of the single antibiotic used. However, there is a clear synergistic effect when using the combination of antibiotics in the bacterial metabolism. Prolonged observation of the activity makes it possible to study re-growth, biofilm formation and late-stage survival of population subsets.
The bacterial species and strain give rise to unique metabolic thermograms
P. aeruginosa
A. baumannii
K. pneumoniae
E. coli
Bacterial planktonic growth in Mueller Hinton media, same experimental conditions as for BMD.
The unique heat flow footprint obtained in calScreener is dependent on the metabolism of the specimen, and this depends on the strain studied, as well as on the culture media and the availability of nutrients within it. calScreener can be employed for both gram-negative and gram-positive bacteria with equal sensitivity.
Multi-center clinical validation
Symcel aims to establish calScreener™ as a new diagnostic device for antibiotic susceptibility testing with key opinion leader labs around Europe during 2018-2020.
Symcel has received one of the largest Horizon 2020 grants ever awarded to a Swedish company, €3.6 million for three clinical studies in 5 different European labs. Read more about this exciting development here and please reach out if you are interested in discovering more.
P. aeruginosa
A. baumannii
P. aeruginosa and A. baumannii planktonic growth in Mueller Hinton media, same experimental conditions as for BMD.
The calScreener™ gives completely flexibility regarding the single or combo treatment, making AST most flexible and relevant.
In these graphs, it can be observed the lack of effect in the metabolism of the culture of the single antibiotic used. However, there is a clear synergistic effect when using the combination of antibiotics in the bacterial metabolism. Prolonged observation of the activity makes it possible to study re-growth, biofilm formation and late-stage survival of population subsets.
The bacterial species and strain give rise to unique metabolic thermograms
P. aeruginosa
A. baumannii
K. pneumoniae
E. coli
Bacterial planktonic growth in Mueller Hinton media, same experimental conditions as for BMD.
The unique heat flow footprint obtained in calScreener is dependent on the metabolism of the specimen, and this depends on the strain studied, as well as on the culture media and the availability of nutrients within it. calScreener can be employed for both gram-negative and gram-positive bacteria with equal sensitivity.
Multi-center clinical validation
Symcel aims to establish calScreener™ as a new diagnostic device for antibiotic susceptibility testing with key opinion leader labs around Europe during 2018-2020.
Symcel has received one of the largest Horizon 2020 grants ever awarded to a Swedish company, €3.6 million for three clinical studies in 5 different European labs. Read more about this exciting development here and please reach out if you are interested in discovering more.
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