細(xì)胞生長動(dòng)力學(xué)生存力測定分析系統(tǒng)-高靈敏型細(xì)胞恒溫量熱代謝測試分析

我們看到別人看不到的東西。我們提供表型反應(yīng)的測量。針對細(xì)胞生物學(xué)優(yōu)化的直接代謝讀數(shù)可實(shí)現(xiàn)更好的檢測和藥物開發(fā)。

• calScreener™
• 實(shí)時(shí)監(jiān)控
• 無標(biāo)簽，無添加劑
• 無損，允許進(jìn)行實(shí)驗(yàn)后分析
• 與細(xì)胞模型無關(guān)-2D，3D，懸浮液，類器官等
• 所有細(xì)胞類型-細(xì)菌，哺乳動(dòng)物細(xì)胞等
• 即用型無菌塑料生長插件
• 48孔板形式，檢測成本低

calScreener™無標(biāo)記測定法使用生物活性監(jiān)測直接監(jiān)測生物系統(tǒng)中的代謝反應(yīng)。我們開發(fā)了di一臺專為細(xì)胞生物學(xué)設(shè)計(jì)的恒溫微量量熱儀?；诔墒斓目茖W(xué)方法進(jìn)行的高精度細(xì)胞代謝監(jiān)測。無論樣品成分和形態(tài)如何，calScreener™均可用于在正確的背景下一次研究所有細(xì)胞參數(shù)的凈效應(yīng)。與使用基于參數(shù)（基因型）檢測的大多數(shù)其他技術(shù)相比，calScreener™是真正的表型（功能性）檢測。

典型應(yīng)用：

Dead or Alive

We provide solutions for rapid effect detection in drug development, exploratory research and in-vitro diagnostics. Direct metabolic monitoring of drug effects on cells and bacteria and ultimately if they live or die.

Microbiology

The calScreener™ allows you to monitor bacterial metabolism in real-time and is used for exploratory research and development of new antibiotics. In-vitro diagnostics focused on antimicrobial susceptibility testing aims to provide a rapid and accurate diagnosis of infections caused by multi-resistant bacteria.

Take control of your microbial culture with continuous visualization of the complete metabolic response to single or combination antibiotic treatment efficacy.

Antimicrobial
Susceptibility Testing

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Biofilm-forming
Bacteria

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Antibiotics
Development

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LEARN ABOUT SYMCEL’S HORIZON 2020 PROJECT ON AST AND ANTIMICROBIAL COMBINATION TESTING

Metabolic Research

The calScreener™ assay is employed to directly measure stimulation or inhibition of energy expenditure and cell growth stimulation in metabolic research and drug development settings, both in 2-Dimensional and 3-Dimensional samples as well as in intact tissue biopsies.

Directly measure thermogenesis upon stimulation of brown tissue or energy expenditure in glucose uptake and insulin sensitivity for diabetes research as classic examples.

Brown Adipose Tissue Thermogenesis

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Drug Discovery & Development

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Anti-cancer drug development and oncology research

Improved oncology-targeting monoclonal antibody and small molecule drug development. The calScreener™ assay is used to directly measure the cell-killing effects of potentially apoptotic antibodies or compounds. The potency and mechanism of action are directly monitored providing a true evaluation of cell survival and cell death kinetics.

MORE ON ONCOLOGY APPLICATIONS

Additional applications

Our analytical instrument can be used for monitoring changes in biological processes caused by physical, chemical or biological stimuli in all cell types. Changes in metabolic activity will cause changes in heat dissipated from the cell, tissue or organism. Depending on the biological process involved different kinetic behaviors are anticipated.

This universal approach makes the technology extremely versatile and not limited to one specific type of assay or question. The calScreener technology has been tested in use for a broad range of applications in addition to microbiology, metabolism and oncology. Follow the link in the title above for a brief summary on some of these and please do reach out for discussions on whatever application may be on your mind.