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          貨物所在地: 北京北京市
          更新時間: 2024-09-02 21:00:07
          期: 2024年9月2日--2025年3月2日
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          BioDent/OsteoProbe活體骨骼質(zhì)量測試分析儀系統(tǒng),BioDent骨質(zhì)量測試分析儀系統(tǒng),OsteoProbe骨質(zhì)量測試分析儀系統(tǒng),活體骨骼測試分系統(tǒng),骨組織參考點壓痕測試分析,bone Reference Point
          活體在體骨骼組織參考點壓痕測量儀基于的參考點壓痕技術(shù),具有離體測量和在體測 (可以直接穿透皮膚探測組織機械特性)量兩種模式。該系統(tǒng)可直接切非破壞性地在體測試分析活體

          詳細(xì)介紹

          BioDent活體骨骼質(zhì)量測試分析儀系統(tǒng)

          BioDent/OsteoProbe活體骨骼質(zhì)量測試分析儀系統(tǒng),BioDent骨質(zhì)量測試分析儀系統(tǒng),OsteoProbe骨質(zhì)量測試分析儀系統(tǒng),活體骨骼測試分系統(tǒng),骨組織參考點壓痕測試分析,bone Reference Point

          BioDent™

          What is BioDent™?

          BioDent™ is a bench-top Reference Point Indentation platform that enables scientists to easily measure the material properties and function of tissues and biomaterials.

          The in vitro to in vivo testing modes set BioDent™ apart from other instruments, enabling the acquisition of data about material properties and function that was previously impossible.

          Learn more about BioDent

          • Why do I need BioDent?

          • How does BioDent work?

          • What does BioDent l me?

          • How easy is BioDent to use?

          • What can I test with BioDent?

           

          Why do I need BioDent?

           

          Direct Measurements

          BioDent allows for direct measurement, rather than a surrogate, of tissue function in a clinically relevant way.

          Ease of Use

          No extensive technical background is necessary to learn how to use BioDent.

          First & Only Solution

          BioDent is the first device of its kind. Direct, clinically relevant measurement of tissues is providing never before available insight into tissue function.

          It is generally understood that material properties are an important contributor to tissue and biomaterial health. However, no instruments have been available to easily measure these properties in the laboratory in a way that can translate into clinical practice – often causing this important information to be excluded from research.  Also, no tools have previously been available to measure tissue material properties in vivo – resulting in frequent exclusion of their evaluation in life science research altogether.

          BioDent™ is the first and only solution for life science researchers to easily and directly obtain clinically measurable material properties.

          How does BioDent™ work?

           

           

          BioDent™ uses a microscopic test probe to touch a tissue or biomaterial and evaluate material function/response. The test probe can be sheathed inside a small cannula reference probe which establishes a reference point on or in the sample.

          In force-controlled mode, BioDent™ measures the distance the test probe moves relative to the reference point as an indication of how much the material gave-way or flowed when pushed on at controlled force.

          For advanced users, a distance-controlled mode BioDent™ measures the force required to push a test probe a predetermined distance into the material, relative to the reference point.

          Learn more about how BioDent™ works.

          What does BioDent™ l me?

          BioDent™ outputs have been used to describe the mechanical effect of tissue health, treatment, and disease. Hard and soft tissues are comprised of many material components that come together to give tissue its desired function. Understanding how tissue function changes due to treatment or disease opens a new perspective on health.

          Depending on your setup, BioDent™ can probe across the micrometer to millimeter length scale in order to provide a robust measure across all material components in the tissue or biomaterial. BioDent™ can also provide previously impossible direct, in vivo measures of tissue function – clinically measurable material properties.

          How easy is it to use BioDent™?

          Like every scientific instrument there is some training required before using BioDent™, however unlike many scientific instruments, no extensive technical background is necessary. Active Life Scientific, Inc. provides all training material with the instrument, sufficient to get a non-technical scientist up and running in a few hours or less.  For Advanced Users, certain BioDent™ configurations offer access to waveform control inputs and data analysis outputs through layered interfaces.

          In just 30 seconds, a trained user can perform a mechanical test.

           

          • Step 1: Attach and position sample.
          • Step 2: Lower BioDent probe to sample.
          • Step 3: Click “measure” to gather data in real time.

          What tissues and biomaterials can I test with BioDent™?

          BioDent™ is designed for in vitro to in vivo testing of a growing number of tissues and biomaterials. Visit Literature to discover the various animals, tissues, and disease/research models already proven on the BioDent™ platform. BioDent™ was initially introduced for hard materials applications, such as bone, however softer materials applications are quickly emerging.

          Can’t find what you’re interested in testing? Contact Us, we’d love to learn about it.

           

           

           

          Translational Research

          Explore publications highlighting the translational potential of Reference Point Indentation (RPI) technology and how it can be used.

           

          In Vivo Research

          Explore publications highlighting the in vivo potential of Reference Point Indentation (RPI) technology and how it can be used.

           

          Ex Vivo

          Explore publications highlighting the versatility of Reference Point Indentation (RPI) technology and how it can be used.

           

          OsteoProbe骨質(zhì)量測試分析儀系統(tǒng)

           

          活體在體非破壞性地測量兩種模式下測試分析活體內(nèi)骨骼組織的硬度、彈性系數(shù)、zui大壓痕距離與壓痕距離增加值等機械特性(其中壓痕距離增加值表示骨折或其他病變組織與正常組織的差異)、測試分析骨內(nèi)之礦物質(zhì)含量及分析骨骼微結(jié)構(gòu),這對于闡明骨科疾病,比如骨質(zhì)疏松癥、關(guān)節(jié)炎等疾病的發(fā)病機制、揭示正常生命機體生長、發(fā)育和衰老的機理和自然規(guī)律、對于闡明機體骨組織疾病的發(fā)病機理及提供診斷和治療的基本原理均都是具有極其重要的理論和現(xiàn)實意義,以便更好的為臨床服務(wù)。

          OsteoProbe®

           

          Quick. Accurate. Innovative. In Vivo.

          The first and only medical device for direct measurement of bone material quality in vivo. Empowering physicians with the ability to measure the material aspects of bone quality for the first time.

          View Publications

           

           

          What is OsteoProbe® ?

          OsteoProbe® RUO

          OsteoProbe® (for research use only in the United States) is a portable handheld microindenter that measures the ability of bone material to resist indentation. Unlike radiological methods (X-ray, DXA and CT) that measure bone mineral density and bone mineral structure, OsteoProbe® measures bone material quaility; an independent component of bone strength.

          OsteoProbe® uses Reference Point Indentation (RPI) technology to investigate the bone material’s ability to resist a localized force (resist separation of mineralized collagen fibrils). This is quantified by the Bone Material Strength index (BMSi).

          Direct Measurements

          Every measurement taken is recorded in OsteoProbe’s software, providing the most accurate data.

          Ease of Use

          OsteoProbe can be used by a physician, nurse, or technician after brief training.

          First & Only Solution

          The first and only medical device(approved in Europe) for direct measurement of bone material qualityin vivo.

          Related Literature

          Bone Material Strength as measured by microindentation in vivo is decreased in patients with fragility fractures independently of Bone Mineral Density

          Journal of Clinical Endocrinology & Metabolism, Dr. Socrates Papapoulos et al, 2015

          Bone Tissue Properties Measurement by Reference Point Indentation in Glucocorticoid-Induced Osteoporosis

          Journal of Bone and Mineral Research, Dr. Adolfo Diez Perez et al, 2015

          In Vivo assessment of bone quality in postmenopausal women with type 2 diabetes

          Journal of Bone and Mineral Research, Dr. Sundeep Khosla et al, 2013

           

           

          What does OsteoProbe® measure?

          Bone Quality Venn Diagram

          OsteoProbe® measures and quantifies material aspects of bone, providing a clearer understanding of Bone Quality. Bone is composed of mineral and organic (Bone Glue) building blocks. Current clinical techniques provide detailed information about the mineral aspects of bone but there limited techniques to provide information about the organic aspects and function. Learn more about Bone Quality.

          In the clinical setting, material properties of Bone Quality have been ignored due to the lack of a method for in vivo measurement. Reference Point Indentation (RPI) is a technique bringing change to the current situation in a clinical research setting. RPI enables physicians and researchers to have an in vivo method for directly measuring material aspects of bone quality. With RPI, physicians and researchers can measure and monitor changes in the material quality of bone.

          Related Literature

          In Vivo assessment of bone quality in postmenopausal women with type 2 diabetes

          Journal of Bone and Mineral Research, Dr. Sundeep Khosla et al, 2013

          Measuring Bone Quality

          Current Rheumatology Reports, Diez-Pérez, A. et al, 2013

          Identifying novel clinical surrogates to assess human bone fracture toughness

          Current Rheumatology Reports, Nyman, J. S. et al, 2015

          The Contribution of the Extracellular Matrix to the Fracture Resistance of Bone

          Curr Osteoporos Rep., Nyman, J. S. et al, 2012

           

           

          How does OsteoProbe® work?

          OsteoProbe® uses Reference Point Indentation (RPI) technology to measure bone material’s ability to resist a localized force. Utilizing a probe specifically designed for percutaneous measurements, OsteoProbe penetrates soft tissue down and touches the bone surface, establishing a local reference point. Once actuated, OsteoProbe measures the bone’s resistance to force and outputs a Bone Material Strength index (BMSi) or Bone Score.

          Learn more about how OsteoProbe® works.

          Related Literature

          A new device for performing reference point indentation without a reference probe

          Review of Scientific Instruments, Dr. Paul Hansma, 2012

          Applications of a New Handheld Reference Point Indentation Instrument Measuring Bone Material Strength

          Journal of Medical Devices, Dr. Paul Hansma, 2013

           

           

          How easy to use is OsteoProbe® ?

          OsteoProbe® was designed with the physician in mind.

          OsteoProbe® allows quick and easy measurement of bone material quality data with minimal training.

          Learn more about using OsteoProbe®.

          Related Literature

          In vivo research from Hospital del Mar, Spain by Prof. Adolfo Diez-Perez

          YouTube, Prof. Adolfo Diez-Perez, 2011

          Osteoprobe Usage on Simulated Soft Tissue by the Hansma Lab

          Vimeo, Dr. Paul Hansma, 2013

           

           

          OsteoProbe®  built to inspire discoveries that benefit human health.

          OsteoProbe®  was invented to empower physicians and researchers with the tool they need to discover how genetics, disease, diet, exercise, and other triggers affect the quality of the bone tissue.

          The bigger picture is that Reference Point Indentation was invented to enable scientists to discover better treatments, medical professionals can deliver better results, and people can live actively throughout their entire life. Learn more about the invention.

          Related Literature

          In Vivo assessment of bone quality in postmenopausal women with type 2 diabetes

          Journal of Bone and Mineral Research, Dr. Sundeep Khosla el al, 2013

          Bone Tissue Properties Measurement by Reference Point Indentation in Glucocorticoid-Induced Osteoporosis

          Journal of Bone and Mineral Research, Dr. Adolfo Diez Perez el al, 2015

          Bone Material Strength as measured by microindentation in vivo is decreased in patients with fragility fractures independently of Bone Mineral Density

          Journal of Clinical Endocrinology & Metabolism, Dr. Socrates Papapoulos et al, 2015

          Are the High Hip Fracture Rates Among Norwegian Women Explained by Impaired Bone Material Properties?

          Journal of Bone and Mineral Research, Dr. Erik Eriksen et al, 2015

           

           

          OsteoProbe® Publications

          • Are the High Hip Fracture Rates Among Norwegian Women Explained by Impaired Bone Material Properties?
            Journal of Bone and Mineral Research, Dr. Erik Eriksen et al, 2015
          • Bone Material Strength as measured by microindentation in vivo is decreased in patients with fragility fractures independently of Bone Mineral Density
            Journal of Clinical Endocrinology & Metabolism, Dr. Socrates Papapoulos et al, 2015
          • Bone Tissue Properties Measurement by Reference Point Indentation in Glucocorticoid-Induced Osteoporosis
            Journal of Bone and Mineral Research, Dr. Adolfo Diez Perez et al, 2015
          • Study of indentation of a sample equine bone using finite element simulation and single cycle reference point indentation
            Journal of the Mechanical Behavior of Biomedical Materials, Dr. Henry Yang et al, 2015
          • In Vivo assessment of bone quality in postmenopausal women with type 2 diabetes
            Journal of Bone and Mineral Research, Dr. Sundeep Khosla et al, 2013
          • Applications of a New Handheld Reference Point Indentation Instrument Measuring Bone Material Strength
            Journal of Medical Devices, Dr. Paul Hansma, 2013
          • A new device for performing reference point indentation without a reference probe
            Review of Scientific Instruments, Dr. Paul Hansma, 2012

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