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世聯(lián)博研（北京）科技有限公司 |
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—— 銷售熱線 ——
18618101725 |
瑞士regenHU廠家的EMC-Bioink™系列生物墨水現(xiàn)成的有五種，但可以針對(duì)特定應(yīng)用進(jìn)行定制。
系列被描述為“非牛頓流體材料，有剪切稀化性質(zhì)，能根據(jù)需要和要求提供促進(jìn)細(xì)胞擴(kuò)增、細(xì)胞生長(zhǎng)和遷移的三維肽納米纖維支架。”
將使研究人員更容易地增材制造出復(fù)雜的、與真實(shí)有機(jī)組織的結(jié)構(gòu)和功能極其相似的結(jié)構(gòu)。通過提供對(duì)機(jī)械強(qiáng)度和細(xì)胞支架的相互作用的控制，EMC-Bioink系列材料可以充當(dāng)獨(dú)立的基質(zhì)，如果需要，也可以整合到一個(gè)結(jié)構(gòu)系統(tǒng)中。
EMC-Bioink有著廣泛的應(yīng)用，可用于各種目的，如研究組織或疾病、藥物發(fā)現(xiàn)、毒性、功效、創(chuàng)造再生植入物等
Our 3DDiscovery™ and BioFactory™ bioprinters offer a broad portfolio of biomaterials for both soft and hard tissue engineering and drug discovery.
This portfolio is comprised of natural and synthetic hydrogels acting as extracellular-matrix environments to support cell growth (ECM-BioInk™), biomaterials for scaffolding to mimic hard tissues (OsteoInk™) and support materials (STARK™).
| Biomaterials | Application | Characteristics |
| HYDROGELS | ECM-a BioInk™ | 3D Cell culture, migration and proliferation assay | Biosynthetic extracellular matrix with Low net charge |
| ECM-b BioInk™ | Biosynthetic extracellular matrix with Mid net charge | ||
| ECM-c BioInk™ | Biosynthetic charge extracellular matrix with High net charge | ||
| ECM-f BioInk™ | Biosynthetic extracellular matrix with Low net charge Functionalized | ||
| ECM-p BioInk™ | Biosynthetic extracellular matrix with Low net charge Functionalized |
| SCAFFOLDING | OsteoInk™ | Calcium Phosphate biomaterial for hard tissue engineering | Calcium phospahte formulation |
| SUPPORT | STARK™ | Support material for Freeform Fabrication | Silicon-based polymer |
ECM-BioInk™, is a peptide nanofiber 3-dimensional scaffold that promotes cell growth and migration.
It utilizes specific peptides that self-assemble from ECM-BioInk™ fluid precursors into highly intertwined hydrated peptide hydrogel fibres when presented with ionic strengths. By inducing a rapid transformation from solution to gel, a peptide nanofiber scaffold is generated.
The ECM-BioInk™ portfolio contains 5 formulations that differ from each other in the electrical net charge which impacts the matrix stiffness and consequently cell proliferation capacity.
BioInk Datasheet
By adjusting the concentration of the ECM-BioInk™ solution, users can control the flexibility of the 3D architecture to meet their application′s specific needs. ECM-BioInk™ is a unique human relevant, synthetic extracellular matrix in which scaffold interaction with cells and small molecules are driven by hydrogen and hydrophobic interactions.
BioInk Datasheet
| Cell type | ECM- a BioInk™ | ECM- b BioInk™ | ECM-c BioInk™ | ECM-f BioInk™ | ECM-f BioInk™ | Experiment |
|---|---|---|---|---|---|---|
| FIBROBLASTS | • | • | • | • | • | Proliferation, Migration |
| Human Embryonic Stem Cells | • | • | • | • | • | Proliferation, Differentiation |
| Human Induced Pluripotent Stem Cells | • | • | • | • | • | Proliferation, Differentiation |
| Human Mesenchemical Stem Cells | • | • | • | • | • | Proliferation, Differentiation |
| Bone Marrow Derived Mesenchemial Stem Cells | • | • | • | • | Proliferation, Differentiation | |
| Adipose Tissue Derived Mesenchemical Stem Cells | • | • | • | • | Proliferation, Differentiation | |
| Human Haemopoetic Stem Cells | • | • | • | • | Proliferation, Differentiation | |
| Human Neuronal Stem Cells | • | • | • | Proliferation, Differentiation | ||
| Cardiac Progenitor Cells | • | • | • | • | • | Proliferation, Differentiation |
| Human Endothelial Cells | • | • | • | Proliferation, Migration | ||
| Primary Neurons | • | • | • | • | Proliferation, Migration | |
| Cardiomyocytes | • | • | • | Proliferation, Migration | ||
| Nucleus Pulposus Cells | • | • | • | Proliferation, Migration | ||
| Hepatocytes | • | • | • | • | Proliferation, Migration | |
| Chrondrocytes | • | • | • | Proliferation, Migration | ||
| Myocytes | • | • | • | • | Proliferation, Migration | |
| Order | Order | Order | Order | Order |
OsteoInk™ is a ready-to-use calcium phosphate paste for scaffolding and structural engineering. OsteoInk™ is a highly osteoconductive biomaterial close to the chemical composition of human bone. Dedicated to hard tissue engineering such as bone, cartilage or structural scaffold manufacturing, OsteoInk™ can be combined during the printing process with our biomaterial product portfolio (e.g ECM-BioInk™) to create complex 3D tissue models.
The uniqueness of BioFactory™ and 3DDiscovery™ printers enables freeform fabrication of tissue models with controlled layers, pore structure and biological composition. It enables scientists to mimic nature by combining OsteoInk™ with hydrogels (natural or synthetic), bioactives, scaffolding or support materials.
BioInk™ is a chemically-defined hydrogel to support growth of different cell types. It allows cell adhesion, mimics the natural extracellular matrix and is biodegradable. BioInk™ is provided as a ready-to-use chemically-defined hydrogel to print 3D tissue models. Exclusively designed for regenHU’s BioFactory™ and 3DDiscovery™ tissue and bio-printers.
A versatile, chemically-defined hydrogel, supporting cell attachment, growth, differentiation and migration. The BioInk™ is suitable for long-term tissue c*tion (in vitro human dermis for up to 7 weeks).
Modular Matrix Tailored to the needs of your cells
Combined with BioFactory™ or 3DDiscovery™ tissue printers, you will be able to create composite tissue models in a layer-by-layer fashioning with spatial control of bioactive components (matrix, cells, proteins) and biomaterials.
BioInk Datasheet
Creation of tissue models of complex bioarchitectures and overhanging structures, in single or composite materials, may require fugitive support materials that act as a temporary scaffold for the structure.
Especially in 3D cell culture & LifeScience applications where extracellular matrix materials (ECM) such as low-viscose hydrogels, collagens or similar are used to encapsulate and deliver bioactives, STARK™ biopolymer enables 3D shape fidelity and bioarchitecture control of cell-laden conceptions.
STARK™ is a biocompatible biopolymer dedicated to hard & soft tissue engineering with either a 3DDiscovery™ or BioFactory™ bioprinting platform. It can be used during the construction process in combination with BioInk™ or OsteoInk™ or any natural or synthetic printable biomaterials.
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