---------- 自身免疫病檢測(cè)試劑盒
背景簡(jiǎn)介
自身免疫抗體是機(jī)體在非正常狀態(tài)下，由機(jī)體自身免疫系統(tǒng)分泌的針對(duì)機(jī)體自身蛋白的抗體。比如：系統(tǒng)性紅斑性狼瘡疾病產(chǎn)生的抗體。自身抗體產(chǎn)生的原因有很多，具體機(jī)理還有待研究。多數(shù)學(xué)者認(rèn)為：一些自身抗體的產(chǎn)生是由于遺傳因素和環(huán)境因素共同作用的結(jié)果，比如：一些病毒性疾病或長(zhǎng)期在處于有毒化學(xué)毒素下，都可以導(dǎo)致自身免疫疾病。自身免疫疾病源與機(jī)體對(duì)自身體內(nèi)或組織產(chǎn)生免疫應(yīng)答。換句話說(shuō)，免疫系統(tǒng)將機(jī)體自身的物質(zhì)誤認(rèn)為病原。這主要局限于一些特定組織：（比如：甲狀腺）。自身免疫疾病的治療主要依賴于免疫調(diào)節(jié)藥物用于降低免疫應(yīng)答。
自身免疫疾病對(duì)機(jī)體的傷害程度取決于自身抗體作用的的器官或組織和器官特異性的自身抗體導(dǎo)致的紊亂程度。那些只對(duì)單一器官作用自身抗體導(dǎo)致的自身免疫疾病很容易發(fā)現(xiàn)，因?yàn)檫@類疾病常常伴有系統(tǒng)的病癥。比如：甲狀腺機(jī)能亢進(jìn)和橋本氏甲狀腺炎。由自身免疫抗體導(dǎo)致的系統(tǒng)性功能紊亂，往往很不易被察覺(jué)。自身抗體可通過(guò)ELISA 方法檢測(cè)?；颊呖赡苡嗅槍?duì)不同抗原的自身抗體。用于自身免疫疾病研究的動(dòng)物模型有很多。已經(jīng)發(fā)現(xiàn)的：18個(gè)自身免疫基因簇中有9個(gè)基因簇與相應(yīng)的動(dòng)物模型在序列上高度保守。動(dòng)物模型被廣泛應(yīng)用于人自身免疫疾病的研究，包括：多發(fā)性硬化癥、糖尿病、風(fēng)濕性關(guān)節(jié)炎、系統(tǒng)性紅斑狼瘡。通過(guò)人為誘導(dǎo)、自然的以及遺傳操作的各種動(dòng)物模型被用于研究自身免疫疾病和相應(yīng)的藥物研究。
美國(guó)Alpha Diagnostic International公司擁有用于檢測(cè)不同種屬的自身免疫抗體的ELISA 檢測(cè)試劑盒，包括：小鼠、大鼠、猴及人。
主要的自身免疫抗體和相關(guān)物及對(duì)應(yīng)的自身免疫疾?。?/span>
自身抗原 | 英文名稱 | 疾病 |
抗核抗體 | Anti-SSA/Roautoantibodies
| 系統(tǒng)性紅斑狼瘡、新生兒心肌梗死、干燥綜合征 |
Anti-SSA/Roautoantibodies | 干燥綜合征 | |
Anti-centromere antibodies
| CREST綜合征 | |
Anti-neuronal nuclear antibody | 眼陣攣 | |
Anti-dsDNA
| 系統(tǒng)性紅斑狼瘡 | |
Anti-Jo1
| 炎性肌病 | |
Anti-RNP
| 混合型結(jié)締組織病 | |
Anti-Smith
| 系統(tǒng)性紅斑狼瘡 | |
Anti-topoisomerase antibodies
| 系統(tǒng)性硬化病 | |
Anti-histone antibodies
| 系統(tǒng)性紅斑狼瘡 | |
抗肌動(dòng)蛋白抗體 | Anti-actin antibodies
| 乳糜瀉病 |
抗循環(huán)瓜氨酸蛋白抗體 | anti-CCP (cyclic citrullinated protein) | 類風(fēng)濕性關(guān)節(jié)炎 |
狼瘡抗凝物 | Lupus anticoagulant
| 系統(tǒng)性紅斑狼瘡 |
抗磷脂綜合征 | ||
抗中性粒細(xì)胞抗體 | Anti-neutrophil cytoplasmic antibody (cANCA/pANCA)
| 韋格納肉芽腫病 |
脈管炎 | ||
類風(fēng)濕因子 | Rheumatoid factor | 類風(fēng)濕性關(guān)節(jié)炎 |
抗平滑肌抗體 | Anti-smooth muscle antibody
| 慢性自身免疫性肝炎 |
抗線粒體抗體 | primary biliary cirrhosis | 原發(fā)性肝硬化 |
甲狀腺過(guò)氧化物酶 | thyroid peroxidase(microsomal)
| 橋本氏甲狀腺炎 |
促甲狀腺激素受體 | Graves' disease | 格雷夫斯病 |
骨氨酸脫羧酶/胰島素 | glutamic acid decarboxylase (GAD)/Insulin | I型糖尿病、多發(fā)性硬化癥 |
自身抗原 | 中文名稱 | 英文名稱 | 貨號(hào) |
Anti-ssDNA
| 人抗單鏈DNA抗體檢測(cè)試劑盒 | Human anti-ssDNA IgG ELISA Kit | 3115 |
小鼠抗單鏈DNA Ig's (total (A+G+M)抗體檢測(cè)試劑盒 | Mouse Anti-ssDNA Ig's (total (A+G+M) ELISA Kit | 5310 | |
小鼠抗單鏈DNA IgG檢測(cè)試劑盒 | Mouse Anti-ssDNA IgG-specific ELISA Kit | 5320 | |
小鼠抗單鏈DNA IgM檢測(cè)試劑盒 | Mouse Anti-ssDNA IgM-specific ELISA Kit | 5330 | |
大鼠抗單鏈DNA IgG檢測(cè)試劑盒 | Rat Anti-ssDNA IgG-specific ELISA Kit | 650-330-DSN | |
猴抗單鏈DNA IgG檢測(cè)試劑盒 | Monkey Anti-ssDNA IgG-specific ELISA Kit | 650-340-DSN | |
Anti-dsDNA | 人抗雙鏈DNA IgG檢測(cè)試劑盒 | Human anti-dsDNA IgG ELISA Kit | 3100 |
人抗雙鏈DNA IgM檢測(cè)試劑盒 | Human anti-dsDNA IgM ELISA Kit | 3105 | |
人抗雙鏈DNA IgA檢測(cè)試劑盒 | Human anti-dsDNA IgA ELISA Kit | 3110 | |
小鼠抗雙鏈DNA總抗體檢測(cè)試劑盒 | Mouse Anti-dsDNA Ig's (Total A+G+M) ELISA Kit | 5110 | |
小鼠抗雙鏈DNA IgG檢測(cè)試劑盒 | Mouse anti-dsDNA IgG-specific ELISA Kit, | 5120 | |
小鼠抗雙鏈DNA IgA檢測(cè)試劑盒 | Mouse anti-dsDNA IgA-specific ELISA Kit | 5120-A | |
小鼠抗雙鏈DNA Ig G1檢測(cè)試劑盒 | Mouse anti-dsDNA IgG1-specific ELISA Kit | 5120-1 | |
小鼠抗雙鏈DNA Ig G2a檢測(cè)試劑盒 | Mouse anti-dsDNA IgG2a-specific ELISA Kit | 5120-2a | |
小鼠抗雙鏈DNA IgG2b檢測(cè)試劑盒 | Mouse anti-dsDNA IgG2b-specific ELISA Kit | 5120-2b | |
小鼠抗雙鏈DNA IgG3檢測(cè)試劑盒 | Mouse anti-dsDNA IgG3-specific ELISA Kit | 5120-3 | |
小鼠抗雙鏈DNA IgE3檢測(cè)試劑盒 | Mouse anti-dsDNA IgE-specific ELISA Kit | 5120-E | |
小鼠抗雙鏈DNA IgM檢測(cè)試劑盒 | Mouse anti-dsDNA IgM-specific ELISA Kit | 5130 | |
大鼠抗雙鏈DNA IgG檢測(cè)試劑盒 | Rat anti-dsDNA IgG-specific ELISA Kit | 650-130-DDN | |
猴抗雙鏈DNA IgG檢測(cè)試劑盒 | Monkey Anti-dsDNA IgG ELISA Kit | 670-100-DNM |
自身抗原 | 中文名稱 | 英文名稱 | 貨號(hào) |
Anti-Nuclear Antibodies (ANA or ENA) | 人抗核抗體檢測(cè)試劑盒 | Human Anti-Nuclear Antibodies (ANA) ELISA Kit | 3200 |
小鼠抗核抗原總抗體檢測(cè)試劑盒 | Mouse Anti-Nuclear Antigens (ANA/ENA) Ig's (total (A+G+M) ) ELISA Kit | 5210 | |
大鼠抗核抗原IgG檢測(cè)試劑盒 | Rat Anti-Nuclear Antigens (ANA/ENA) IgG-specific ELISA Kit | 650-230-ANA | |
猴抗核抗原IgG檢測(cè)試劑盒 | Monkey Anti-ANA (Anti-nuclear Antigens/ENA) IgG ELISA Kit | 670-110-ANM | |
Anti-SSA/Ro (Sjogren Syndrome A) | 人抗干燥綜合征A 抗原IgG檢測(cè)試劑盒 | Human anti-SS-A (60 Kda/Ro IgG ELISA Kit | 3210-SSA |
人抗干燥綜合征A 抗原IgG總抗體檢測(cè)試劑盒 | Mouse Anti-SSA/Ro Ig's (total (A+G+M) ELISA Kit | 5710 | |
Anti-SSB/La ((Sjogren Syndrome B) | 人抗干燥綜合征B 抗原IgG檢測(cè)試劑盒 | Human anti-SS-B/La IgG ELISA Kit | 3220-SSB |
Anti-Sm (Smith antigen) | 人抗史密斯抗原IgG檢測(cè)試劑盒 | Human Anti-Smith antigen (Sm) IgG ELISA kit | 3300-100-SMG |
小鼠抗史密斯抗原總抗體檢測(cè)試劑盒 | Mouse Anti-Sm Ig's (total (A+G+M) ELISA Kit | 5405 | |
Anti-RNP (ribonucleoprotein) | 人抗核糖核蛋白IgG檢測(cè)試劑盒 | Human Anti-RNP (RNP-70) IgG ELISA kit | 3300-120-RNG |
小鼠抗核糖核蛋白總抗體檢測(cè)試劑盒 | Mouse Anti-nRNP Ig's (total (A+G+M) ELISA Kit | 5410 | |
Anti-Sm/RNP | 人抗史密斯抗原/核糖核蛋白檢測(cè)試劑盒 | Human Anti-Smith antigen/RNP (Sm/RNP) IgG ELISA kit | 3300-110-SRG |
RF (Rheumatoid Factors) | 人抗類風(fēng)濕因子IgG檢測(cè)試劑盒 | Human Rheumatoid Factors IgG (RF) ELISA Kit | 3000-110-RFG |
人抗類風(fēng)濕因子IgM檢測(cè)試劑盒(半定量) | Human Rheumatoid Factors IgM (RF) ELISA Kit Semi-Quantitative | 3000-100-RFM | |
人抗類風(fēng)濕IgA檢測(cè)試劑盒 | Human Rheumatoid Factors IgA (RF) ELISA Kit | 3000-105-RFA | |
小鼠抗類風(fēng)濕因子總抗體檢測(cè)試劑盒 | Mouse Rheumatoid Factor (RF) Ig's (total (A+G+M) ELISA kit | 6200 | |
小鼠抗胰島素IgG檢測(cè)試劑盒 | Mouse Anti-Insulin IgG ELISA Kit | 3700-MIG | |
小鼠抗IgM 檢測(cè)試劑盒 | Mouse Anti-Insulin IgM ELISA Kit | 3710-MIM | |
大鼠抗IgM 檢測(cè)試劑盒 | Rat Anti-Insulin IgM ELISA Kit | 3760-RIM |
自身抗原 | 中文名稱 | 英文名稱 | 貨號(hào) |
Anti-PCNA | 人抗增殖細(xì)胞抗原IgG檢測(cè)試劑盒 | Human Anti-Proliferating Cell Nuclear Antigen (PCNA) IgG ELISA kit | 5020 |
Circulating immune complexes (CIC) | 小鼠循環(huán)免疫復(fù)合物總抗體檢測(cè)試劑盒 | Mouse Circulating Immune Complexes (CIC) Ig's (total (A+G+M) ELISA kit | 5900 |
人抗C1q補(bǔ)體IgG檢測(cè)試劑盒 | Human Anti-C1q IgG ELISA Kit | 2950 | |
Anti-Cyclic Citrullinated Peptide (CCP) | 人抗環(huán)瓜氨酸肽IgG ELISA 試劑盒 | Human Anti-Cyclic Citrullinated Peptide (CCP) IgG ELISA kit | 3300-340-CCG |
小鼠抗環(huán)瓜氨酸肽IgG 檢測(cè)試劑盒 | Mouse Anti-Cyclic Citrullinated Peptide (Anti-CCP) IgG ELISA Kit | 680-400-CCG | |
小鼠抗環(huán)瓜氨酸肽IgM 檢測(cè)試劑盒 | Mouse Anti-Cyclic Citrullinated Peptide (Anti-CCP) IgM ELISA Kit | 680-410-CCM | |
大鼠抗環(huán)瓜氨酸肽IgG 檢測(cè)試劑盒 | Rat Anti-Cyclic Citrullinated Peptide (Anti-CCP) IgG ELISA Kit | 680-420-CCG | |
大鼠抗環(huán)瓜氨酸肽IgM檢測(cè)試劑盒 | Rat Anti-Cyclic Citrullinated Peptide (Anti-CCP) IgM ELISA Kit | 680-430-CCM | |
Anti-Histones | 人抗組蛋白IgG檢測(cè)試劑盒 | Human Anti-Histones IgG ELISA kit | 3300-130-HNG |
小鼠抗組蛋白IgG檢測(cè)試劑盒 | Mouse Anti-Histones Ig's (total (A+G+M) ELISA Kit | 5610 | |
大鼠抗組蛋白IgG檢測(cè)試劑盒 | Rat Anti-Histones IgG-specific ELISA Kit | 650-430-HIS | |
猴抗組蛋白IgG ELISA 試劑盒 | Monkey Anti-Histones IgG ELISA Kit | 670-120-HIM | |
Anti-Scl70 (Scleroderma 70 Kda) | 人抗硬皮病/DNA 拓?fù)洚悩?gòu)酶IgG檢測(cè)試劑盒 | Human Anti-Scl-70 (Scl70/Scleroderma 70 Kda/DNA-topoisomerase-1) IgG ELISA kit | 3300-140-SCG |
小鼠抗硬皮病總抗體檢測(cè)試劑盒 | Mouse anti-Scl70 Ig's (total (A+G+M) ELISA Kit | 6110 | |
Anti-Jo-1 | 人抗Jo-1抗原IgG檢測(cè)試劑盒 | Human Anti-Jo-1 (Scleroderma 70 Kda/DNA-topoisomerase-1) IgG ELISA kit | 3300-150-JOG |
小鼠抗Jo-1抗原總抗體檢測(cè)試劑盒 | Mouse Anti-Jo-1 Ig's (total) ELISA Kit, 96 tests, Quantitative | 6005 | |
Anti-Fodrin | 人抗胞襯蛋白IgG檢測(cè)試劑盒 | Human Anti-Alpha Fodrin IgG ELISA kit | 3300-160-AFG |
Anti-Cardiolipin | 人抗心磷脂IgG檢測(cè)試劑盒 | Human Anti-Cardiolipin IgG ELISA kit | 3300-170-CLG |
人抗心磷脂IgM檢測(cè)試劑盒 | Human Anti-Cardiolipin IgM ELISA kit | 3300-175-CLM |
自身抗原 | 中文名稱 | 英文名稱 | 貨號(hào) |
| 人抗心磷脂IgA檢測(cè)試劑盒 | Human Anti-Cardiolipin IgA ELISA kit | 3300-185-CLA |
小鼠抗心磷脂總抗體檢測(cè)試劑盒 | Mouse Anti-Cardiolipin Ig's (A+G+M) ELISA kit | 5510 | |
大鼠抗心磷脂總抗體檢測(cè)試劑盒 | Rat Anti-Cardiolipin Ig's (A+G+M) ELISA kit | 5520 | |
Anti-Beta 2 Glycoprotein (B2GP) | 人抗β2糖蛋白IgG檢測(cè)試劑盒 | Human Anti-Beta2-Glycoprotein 1 (B2GP1) IgG ELISA kit | 3300-190-B2G |
人抗β2糖蛋白IgM檢測(cè)試劑盒 | Human Anti-Beta2-Glycoprotein 1 (B2GP1) IgM ELISA kit | 3300-195-B2M | |
人抗β2糖蛋白IgA檢測(cè)試劑盒 | Human Anti-Beta2-Glycoprotein 1 IgA ELISA kit | 3300-200-B2A | |
Anti-Phospholipid Screen | 人抗磷脂抗體IgG/IgM試劑盒 | Human Anti-Phospholipid Screen IgG/IgM ELISA kit | 3300-200-APS |
Anti-Phosphotidyl Serine | 人抗磷酯酰絲氨酸IgG/IgM試劑盒 | Human Anti-Phosphatidyl serine IgG/IgM ELISA kit | 3300-210-PSS |
Anti-Phosphotidyl Inositol | 人抗磷酯酰肌醇IgG/IgM 檢測(cè)試劑盒 | Human Anti-Phosphotidyl Inositol IgG/IgM ELISA kit | 3300-215-PIS |
Anti-Phosphotidic Acid | 人抗磷脂酸IgG/IgM檢測(cè)試劑盒 | Human Anti-Phosphotidic Acid IgG/IgM ELISA kit | 3300-220-PAS |
人抗磷脂酸IgG檢測(cè)試劑盒 | Human Anti-Phosphocholine (anti-PC) IgG ELISA Kit | 680-300-PCG | |
Anti-Phosphocholine (PC)
| 人抗磷酸膽堿IgM檢測(cè)試劑盒 | Human Anti-Phosphocholine (anti-PC) IgM ELISA Kit | 680-310-PCM |
小鼠抗磷酸膽堿IgG檢測(cè)試劑盒 | Mouse Anti-Phosphocholine (anti-PC) IgG ELISA Kit | 680-100-PCG | |
小鼠抗磷酸膽堿IgM檢測(cè)試劑盒 | Mouse Anti-Phosphocholine (anti-PC) IgM ELISA Kit | 680-110-PCM | |
大鼠抗磷酸膽堿IgG檢測(cè)試劑盒 | Rat Anti-Phosphocholine (anti-PC) IgG ELISA Kit | 680-200-PCG | |
大鼠抗磷酸膽堿IgM檢測(cè)試劑盒 | Rat Anti-Phosphocholine (anti-PC) IgM ELISA Kit | 680-210-PCM | |
Anti-Prothrombin | 人抗凝血素IgG/IgM檢測(cè)試劑盒 | Human Anti-Prothrombin IgG/IgM ELISA kit | 3300-230-APG |
人抗凝血素IgA檢測(cè)試劑盒 | Human Anti-Prothrombin IgA ELISA kit | 3300-235- APA | |
Anti-Annexin V | 人抗膜聯(lián)蛋白V | Human Anti-Annexin V IgG ELISA kit | 3300-240-AVA |
Anti-Neutrophil Cytoplasmic Antibody (ANCA ) Screen | 人抗中性粒細(xì)胞細(xì)胞質(zhì)PR3/MPO IgG檢測(cè)試劑盒 | Human ANCA Screen (Anti-PR3 and Anti-MPO) IgG ELISA kit | 3300-250-ANG |
自身抗原 | 中文名稱 | 英文名稱 | 貨號(hào) |
ANCA (Anti-PR3) | 人抗中性粒細(xì)胞細(xì)胞質(zhì)PR3 IgG檢測(cè)試 | Human ANCA (Anti-PR3) IgG ELISA kit | 3300-255-PRG |
ANCA (Anti-MPO) | 人抗中性粒細(xì)胞細(xì)胞質(zhì)MPO IgG檢測(cè)試劑盒 | Human ANCA (Anti-MPO) IgG ELISA kit | 3300-265-MPG |
Anti-glomerular basement membrane (GBM) | 人抗腎小球基底膜IgG檢測(cè)試劑盒 | Human Anti-glomerular basement membrane (GBM) IgG ELISA kit | 3300-270-GBG |
Anti- bactericidal permeability increasing (BPI) | 人抗殺菌滲透增強(qiáng)蛋白 IgG檢測(cè)試劑盒 | Human Anti-bactericidal permeability increasing (BPI) protein IgG ELISA kit, | 3300-280-BPG |
Anti-Elastase | 人抗彈性蛋白酶IgG檢測(cè)試劑盒 | Human Anti-Elastase IgG ELISA kit | 3300-290-ELG |
Anti-Gliadin | 人抗醇溶蛋白IgG檢測(cè)試劑盒 | Human Anti-Gliadin IgG ELISA kit | 3300-300-GLG |
人抗醇溶蛋白IgM檢測(cè)試劑盒 | Human Anti-Gliadin IgM ELISA kit | 3300-305-GLM | |
人抗醇溶蛋白IgA檢測(cè)試劑盒 | Human Anti-Gliadin IgA ELISA kit | 3300-310-GLA | |
Anti-Parietal Cell | 人抗旁細(xì)胞IgG檢測(cè)試劑盒 | Human Anti-Parietal cell (alpha and beta subunits of the Parietal Cell (H//K/ATPase) IgG ELISA kit | 3300-315-PRG |
ASCA (anti-S. cerevisiae Antibodies or anti-mannan) | 人抗釀酒酵母IgA/IgG 檢測(cè)試劑盒 | Human Anti-ASCA (mannan from Saccharomyces cerevisiae) IgA/IgG ELISA kit | 3300-320-ASC |
人抗釀酒酵母IgG 檢測(cè)試劑盒 | Mouse Anti-ASCA (anti-S. cerevisiae Antibodies or anti-mannan) IgG ELISA Kit | 680-500-ASG | |
人抗釀酒酵母IgM 檢測(cè)試劑盒 | Mouse Anti-ASCA (anti-S. cerevisiae Antibodies or anti-mannan) IgM ELISA Kit | 680-505-ASM | |
小鼠抗釀酒酵母IgA 檢測(cè)試劑盒 | Mouse Anti-ASCA (anti-S. cerevisiae Antibodies or anti-mannan) IgA ELISA Kit | 680-510-ASA | |
大鼠抗釀酒酵母IgG 檢測(cè)試劑盒 | Rat Anti-ASCA (anti-S. cerevisiae Antibodies or anti-mannan) IgG ELISA Kit | 680-520-ASG | |
大鼠抗釀酒酵母IgM 檢測(cè)試劑盒 | Rat Anti-ASCA (anti-S. cerevisiae Antibodies or anti-mannan) IgM ELISA Kit | 680-525-ASM | |
大鼠抗釀酒酵母IgA 檢測(cè)試劑盒 | Rat Anti-ASCA (anti-S. cerevisiae Antibodies or anti-mannan) IgA ELISA Kit | 680-530-ASA |
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