Tocris bioscience是位于英國布里斯托爾(Bristol)的高品質試劑提供商,共有2000多種產(chǎn)品,主要集中在神經(jīng)科學和信號傳導領域,產(chǎn)品類型包括小分子、多肽、抗體、配體和化合物篩選文庫等,主要產(chǎn)品包括GPCR ligands,神經(jīng)傳遞素,離子通道調(diào)控劑,信號通路抑制劑等,這些產(chǎn)品被廣泛選擇性地用于阻斷或激活生物學通路。Tocris是世界上神經(jīng)科學研究領域*的,其生產(chǎn)的影響神經(jīng)系統(tǒng)的化學物質被多次引用,這些物質很多都來自Jeff Watkins(Tocris 的創(chuàng)立人)在Bristol大學原創(chuàng)性的研究工作。 Tocris 產(chǎn)品特點: Unique range:廣泛收集來自藥物研究公司和大學的正式許可的化合物 Regularly first to market:新穎的*的產(chǎn)品 Highest standards of product quality:市場上純度zui高的產(chǎn)品,一般大于99% Expert service:提供專家技術服務 Excellent value:質量好價格中等 為感謝廣大科研工作者在2009年生化大會上對Tocris的大力支持和厚愛,吉泰生物特聯(lián)合Tocris 進行特色抑制劑產(chǎn)品*活動,主要為激酶、脫氫酶、受體和信號通路的抑制劑,歡迎大家多多選購。 貨號 | 產(chǎn)品名稱 | 規(guī)格 | 目錄價(RMB) | 活動價(RMB) | 生物學活性 | 2999 | RWJ 67657 | 10 mg | 2579 | 1548 | Selective p38α and p38β inhibitor (IC50 values are 1 and 11 μM respectively) that displays no activity at p38γ, p38δ and a range of other kinases. Potently inhibits TNF-α and IL-1β release (IC50 values are 3 and 11 nM respectively) and suppresses HIV-1 replication in T-cells in vitro. Displays cardioprotective and anti-inflammatory activity in vivo. Orally active. | 2999 | RWJ 67657 | 50 mg | 11396 | 6838 | 3291 | PF 915275 | 10 mg | 2104 | 1262 | Potent and selective 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) inhibitor (Ki = 2.3 nM) that displays little activity at 11βHSD2 (1.5% inhibition at 10 μM). Inhibits the conversion of prednisone to prednisolone in human hepatocytes in vitro (EC50 = 15 nM) and has antidiabetic activity in vivo. Orally active. | 3291 | PF 915275 | 50 mg | 9073 | 5444 | 3304 | SU 16f | 10 mg | 2579 | 1548 | Potent and selective plaet-derived growth factor receptor β (PDGFRβ) inhibitor (IC50 = 10 nM) that displays > 14-fold, > 229-fold and > 10000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 = 0.11 μM). | 3304 | SU 16f | 50 mg | 11396 | 6838 | 3341 | JK 184 | 10 mg | 2287 | 1372 | Potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI50 = 3 - 21 nM) and in human xenografts in vivo. Inhibits alcohol dehydrogenase 7 (Adh7) (IC50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro. | 3341 | JK 184 | 50 mg | 9951 | 5971 | 同時,吉泰生物還提供Tocris 在本次展會上展出的部分精美資料,歡迎感興趣的研究人員致電吉泰市場部-234或到tech@genetimes.com.cn索取。資料列示如下: 名稱 | 簡介 | Ion Channels: Calcium or Potassium or Sodium | 介紹了Tocris與鈣\鉀\鈉離子通道相關的開啟劑、激活劑、抑制劑、阻斷劑等 | Pain | 介紹了Tocris與疼痛感覺相關的受體、酶、離子通道等的抵抗劑、抑制劑、阻斷劑等 | Cell Cycle:Mitosis or G1,G2 and S | 介紹了Tocris與細胞周期有絲分裂相關的微管、激酶等的抑制劑等 | MAPK or Cytokine Signalling | 介紹了Tocris與MAPK/細胞因子信號通路相關的多種激酶等的抑制劑等 | Angiogenesis | 介紹了Tocris與血管生成相關的受體、酶、激酶、信號通路等的抑制劑、激活劑等 | Apoptosis | 介紹了Tocris與凋亡相關的抑制劑、誘導劑等 | PPAR Ligands | 介紹了Tocris與PPAR相關的抵抗劑、抑制劑等 | Growth Factor Receptors/ Opioid Receptors/ GABA/ Dopaminergics/ Adrenergics/ Serotonergics/ AMPK/ Adenosine/ Endocrinology/ Kinase research…… | |
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