Product name:Anti-RANK antibody [9A725] (Phycoerythrin)...
Description
Mouse monoclonal [9A725] to RANK (Phycoerythrin)
ConjugationPhycoerythrin. Ex: 488nm, Em: 575nm
Tested applicationsFlow Cyt
Species reactivity
Reacts with: Mouse, Human
Immunogen
A fusion protein containing amino acid residues 326-616 of human RANK.
EpitopeThis antibody recognizes an epitope located between amino acid residues 330-427 of human RANK.
Positive control
- RAW cells

Properties

FormLiquid
Storage instructionsStore at +4°C.
Storage bufferPreservative: 0.05% Sodium Azide
Constituents: PBS
Concentration 50 µg at 0.5 mg/ml
PurityProtein G purified
Clonality Monoclonal
Clone number9A725
IsotypeIgG1
Light chain typekappa
Research Areas
- Immunology
- Innate Immunity
- Cytokines
- TNF Superfamily
- Signal Transduction
- Adapters
- Transmembrane
- Signal Transduction
- Growth Factors/Hormones
- TNF
- Signal Transduction
- Cytoskeleton / ECM
- Extracellular Matrix
- Structures
- Bone
- Cardiovascular
- Atherosclerosis
- Vascular Inflammation
- Inflammatory mediators

Applications

Our Abpromise guarantee covers the use of ab45092 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application	Notes
Flow Cyt	Flow Cyt: Use 0.5-2µg for 10⁶ cells. (intracellular).

Target

FunctionReceptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.
Tissue specificityUbiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.
Involvement in diseaseDefects in TNFRSF11A are the cause of familial expansile osteolysis (FEO) [MIM:174810]. FEO is a rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. The osteolytic lesions develop usually in the long bones during early adulthood. FEO is often associated with early onset deafness and loss of dentition.
Defects in TNFRSF11A are a cause of Paget disease of bone type 2 (PDB2) [MIM:602080]; also known as familial Paget disease of bone. PDB2 is a bone-remodeling disorder with clinical similarities to FEO. Unlike FEO, however, affected individuals have involvement of the axial skeleton with lesions in the spine, pelvis and skull.
Defects in TNFRSF11A are the cause of osteopetrosis autosomal recessive type 7 (OPTB7) [MIM:612301]; also called osteoclast-poor osteopetrosis with hypogammaglobulinemia. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. OPTB7 is characterized by paucity of osteoclasts, suggesting a molecular defect in osteoclast development. OPTB7 is associated with hypogammaglobulinemia.
Sequence similaritiesContains 4 TNFR-Cys repeats.
Cellular localizationMembrane.
Information by UniProt
Database links
- Entrez Gene: 8792 Human
- Entrez Gene: 21934 Mouse
- Omim: 603499 Human
- SwissProt: Q9Y6Q6 Human
- SwissProt: O35305 Mouse
- Unigene: 204044 Human
- Unigene: 6251 Mouse
Alternative names
- Activator of NFKB antibody
- Activator of NFKB antibody
- CD 265 antibody

Anti-RANK antibody [9A725] (Phycoerythrin) images

Flow Cytometry - RANK antibody [9A725] (Phycoerythrin) (ab45092)
Intracellular flow analysis of RANK in RAW cells using 0.5 µg of ab45092. Green histogram represents isotype control; red represents ab45092.

公司介紹：

Abcam位于英國的劍橋科學(xué)園，成立于1998年，專門生產(chǎn)和分銷研究型抗體。主要?jiǎng)?chuàng)立人Jonathan Milner和實(shí)驗(yàn)室同事構(gòu)思成立一間了解科研人員需要的網(wǎng)上抗體公司，理念是Abcam銷售質(zhì)量高的抗體，并提供zui全面、誠實(shí)、時(shí)新的說明書，快速的送貨服務(wù)，及高效率的顧客和服務(wù)。我們的在線目錄(www.hystemcell.cn) 已有差不多100,000種抗體和試劑，并不斷添加，供應(yīng)予百多個(gè)國家。Abcam于2005年11月在倫敦證券交易所上市，在美國馬薩諸塞州、日本東京及香港均設(shè)有分公司。

Abcam 一直致力加強(qiáng)產(chǎn)品線，為使研究員更容易找到蛋白質(zhì)研究試劑產(chǎn)品，在2011并購了美國的MitoSciences公司，加強(qiáng)了免疫分析方面的產(chǎn)品供應(yīng)；同年也并購了英國的Ascent Scientific 公司，開展了生化試劑的供應(yīng)。在2012年，Abcam并購了美國的Epitomics 公司，成為一家有的RabMAbs® 供應(yīng)商。

Abcam 的目標(biāo)是給世界上的抗體建立zui大的在線目錄，為各地科學(xué)家提供*產(chǎn)品，成為各國科學(xué)界的重要伙伴。我們?yōu)樗挟a(chǎn)品提供來使客戶獲得預(yù)期的結(jié) 果。為提供高質(zhì)量的抗體來指向盡可能多的靶蛋白，我們盡所能在盡可能多的應(yīng)用和物種中檢測每種抗體。我們相信誠信才是上策，在我們的上會(huì)發(fā)布有關(guān)我們每一種產(chǎn)品的盡可能多的信息。

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Abcam ab12616Rabbit polyclonal to GPCR TGR750ug3996GPCR LS195564hystemcell一抗

Abcam ab1262Mouse monoclonal [GA90] to CD45500ul3996CD45hystemcell一抗

Abcam ab12623Rabbit polyclonal to IL3 （Biotin）25ug3996IL-3hystemcell一抗

Abcam ab1263Goat polyclonal to Myc tag （FITC）100ug3996Myc taghystemcell一抗

Abcam ab12631HIF Prolyl Hydroxylases panel1kit7049HIF Prolyl Hydroxylases panel試劑盒及其他產(chǎn)品試劑盒

Abcam ab1264Mouse IgG1 （HybIgG1）（FITC） - Isotype control1ml3996Mouse IgG1hystemcell同型對(duì)照

Abcam ab1265Goat polyclonal to HA tag （HRP）100ug3996HA taghystemcell一抗

Abcam ab12650Rabbit polyclonal to IL16 （Biotin）25ug3996IL-16hystemcell一抗

Abcam ab12656Rabbit polyclonal to IP10 （Biotin）25ug3996IP10hystemcell一抗

Abcam ab1266Goat polyclonal to HA tag （FITC）250ug3996HA taghystemcell一抗

Abcam ab1267Goat polyclonal to Glu-Glu tag （HRP）100ug3996Glu-Glu taghystemcell一抗

Abcam ab12675Rabbit polyclonal to GPCR MCH250ug3996GPCR MCH2hystemcell一抗

Abcam ab12678Rabbit polyclonal to GPR 17950ug4940GPCR AGR9hystemcell一抗

Abcam ab1268Goat polyclonal to Glu-Glu tag （FITC）250ug3996Glu-Glu taghystemcell一抗

Abcam ab12680Rabbit polyclonal to D650ug3996GPCR D6hystemcell一抗

Abcam ab12209Mouse monoclonal [mAbcam 12209] to Histone H3 （tri methyl K4） - ChIP Grade100ug3885Histone H3hystemcell一抗

Abcam ab1221Rabbit polyclonal to Ovalbumin1mg4418Ovalbuminhystemcell一抗

Abcam ab12210Mouse monoclonal [AZ27] to PLK1100ug3996Polo like kinasehystemcell一抗

Abcam ab12211Mouse monoclonal [AZ34] to PLK1100ug3996Polo like kinasehystemcell一抗

Abcam ab12212Mouse monoclonal [AZ44] to PLK1100ug3996Polo like kinasehystemcell一抗

Abcam ab12213Goat polyclonal to c-Myc （HRP）50ug3996c-Mychystemcell一抗

Abcam ab12214Mouse monoclonal to Treponema pallidum100ug3996Treponema pallidumhystemcell一抗

Abcam ab12217Mouse monoclonal [CSL1-5] to Calpastatin50ug3996Calpastatinhystemcell一抗

Abcam ab12219Mouse monoclonal [BU6-4] to BrdU50ug3996BrdUhystemcell一抗

Abcam ab1222Rabbit polyclonal to Superoxide Dismutase 1100ul3996SOD,Superoxide Dismutasehystemcell一抗

Abcam ab1222Rabbit polyclonal to Superoxide Dismutase 11ml3996SOD,Superoxide Dismutasehystemcell一抗

Abcam ab12220Mouse monoclonal [GTS-1] to Heme Oxygenase 150ug3996HO-1,Heme Oxygenase 1hystemcell一抗

Abcam ab12221Rabbit polyclonal to N Cadherin100ug4418N Cadherinhystemcell一抗

Abcam ab12222Mouse monoclonal [NCC-CAD-299] to P cadherin50ug3996P cadherinhystemcell一抗

Abcam ab12223Mouse monoclonal [10C3] to KDEL - ER Marker100ug4418KDELhystemcell一抗

Abcam ab12228Mouse monoclonal [UC1MT] to Metallothionein100ug4418Metallothioneinhystemcell一抗

Abcam ab1223Rabbit polyclonal to Transferrin10mg4218Transferrinhystemcell一抗

Abcam ab12231Mouse monoclonal [3] to Amphiphysin50ug3996Amphiphysinhystemcell一抗

Abcam ab12233Rabbit polyclonal to Calcineurin A50ug3996Calcineurin Ahystemcell一抗

Abcam ab12234Rabbit polyclonal to Rabphilin 3A50ug3996Rabphilin 3Ahystemcell一抗

Abcam ab12239Rabbit polyclonal to Synapsin I50ug3996Synapsin Ihystemcell一抗

Abcam ab1224Rabbit polyclonal to Cyclin D1100ul4285Cyclin D1hystemcell一抗

Abcam ab12241Rabbit polyclonal to Chromogranin C100ul3996Secretogranin IIhystemcell一抗

Abcam ab12242Rabbit polyclonal to Chromogranin B100ul3996Chromogranin Bhystemcell一抗

Abcam ab12243Chicken polyclonal to Raspberry Bushy Dwarf Virus Coat Protein125ug3996Raspberry Bushy Dwarf Virus Coat Proteinhystemcell一抗

Abcam ab12244Chicken polyclonal to Tomato Spotted Wilt Virus Core Protein125ug3996Tomato Spotted Wilt Virus Core Proteinhystemcell一抗

Abcam ab12246Mouse monoclonal to Staphylococcus Enterotoxin A100ug3996Enterotoxin Ahystemcell一抗

Abcam ab12249Rabbit polyclonal to TRPC650ul4274TRPC6hystemcell一抗

Abcam ab1225Mouse monoclonal [BB12+CB19] to CD3+CD19 （Dual color: FITC+PE）500ul3996CD3/CD19hystemcell一抗

Abcam ab12251Mouse monoclonal to Beta Lactamase500ug3996Beta Lactamasehystemcell一抗

Abcam ab12252Mouse monoclonal to Beta Lactamase500ug3996Beta Lactamasehystemcell一抗

Abcam ab12253Rabbit polyclonal to Respiratory Syncytial Virus 50ug3996RSVhystemcell一抗

Abcam ab12254Mouse monoclonal [AS61] to EDG325ug3996EDG3hystemcell一抗

Abcam ab1226Mouse monoclonal [BB12+LN3] to CD3+HLA Class II （Dual color: FITC+PE）500ul3996CD3/HLA-DRhystemcell一抗

Abcam ab12261Rabbit polyclonal to Nurr1100ug3996Nurr1hystemcell一抗

Abcam ab12265Rabbit polyclonal to beta Amyloid 1-40100ul3996beta Amyloid 1-40hystemcell一抗

Abcam ab12266Mouse monoclonal [DE2B4] to Amyloid Precursor Protein1ml3996Amyloid Precursor Protein,APPhystemcell一抗

Abcam ab12267Rabbit polyclonal to beta Amyloid 1-42100ul3996beta Amyloid 1-42hystemcell一抗