Protoxin I / ProTx-I 

Blocker of voltage-gated sodium channels(電壓門控鈉通道阻斷劑)

Protoxin I (ProTx-I; β-theraphotoxin-Tp1a) is a toxin that was originally isolated from the venom of Thrixopelma pruriens (Peruvian green velvet tarantula). This toxin reversibly inhibits the tetrodotoxin (TTX)-resistant channel Na_v1.8(IC₅₀ = 27 nM) and Na_v1.2, Na_v1.5 and Na_v1.7 with IC₅₀ values between 50 and 100 nM. Furthermore, ProTx-I shifts the voltage dependence activity of T-type Ca_v3.1 channels (IC₅₀= 50 nM) without affecting the voltage dependence of inactivation. ProTx-I is a valuable tool to discriminate between Ca_v3.1 and Ca_v3.2.  
 

ProTx-I 技術資料

氨基酸序列：

Glu-Cys²-Arg-Tyr-Trp-Leu-Gly-Gly-Cys⁹-Ser-Ala-Gly-Gln-Thr-Cys¹⁵-Cys¹⁶-Lys-His-Leu-Val-Cys²¹-Ser-Arg-Arg-His-Gly-Trp-Cys²⁸-Val-Trp-Asp-Gly-Thr-Phe-Ser 

二硫鍵：Cys²-Cys¹⁶, Cys⁹-Cys²¹, Cys¹⁵-Cys²⁸ 

長度 (aa)：35 

分子式： C₁₇₁H₂₄₅N₅₃O₄₇S₆ 

分子量： 3987.50 Da 

外觀：White lyophilized solid 

可溶性：water or saline buffer 

CAS 號：Not available 

來源：Synthetic  

純度：> 95 %

產(chǎn)品信息