MT7 – Muscarinic Toxin 7（毒蕈堿毒素7）

Blocker of M1-subtype of muscarinic receptor

毒蕈堿型受體M1亞型阻斷劑

Muscarinic toxin 7 (MT7 – m1-toxin 1) has been isolated from the venom of the green mamba (Dendroaspis Angusticeps). MT7 potently blocks M1-subtype of muscarinic acetylcholine receptors at a subnanomolar affintiy. Muscarinic acetylcholine receptors are G-protein coupled receptors that mediate the metabotropic effects of acetylcholine. M1-type muscarinic acetylcholine receptors are well known therapeutic targets to improve cognitive functions in patients with Alzheimer disease. Contrary to many ligands that target mAChRs (pirenzepine, carbamoylcholine chloride, 4-DAMP or atropine), MT7 is the most selective M1-subtype antagonist as it is about 10,000 times more selective for M1-subtype than other subtypes. MT7 toxin is an ideal tool to identify the muscarinic receptor subtype expression in tissues for example. MT7 toxinbelongs to the three finger toxin family such as rho-Da1a.

MT7 – Muscarinic Toxin 7（毒蕈堿毒素7）技術(shù)資料

氨基酸序列：

LTC³VKSNSIWFPTSEDC¹⁷PDGQNLC²⁴FKRWQYISPRMYDFTRGC⁴²AATC⁴⁶PKAEYRDVINC⁵⁷C⁵⁸GTDKC⁶³NK

二硫鍵： Cys³-Cys²⁴, Cys¹⁷-Cys⁴², Cys⁴⁶-Cys⁵⁷, Cys⁵⁸-Cys⁶³

長(zhǎng)度 (aa)： 65

分子式：C₃₂₂H₄₈₄N₉₀O₉₈S₉

分子量：7472.53 Da

外觀：White lyophilized solid

可溶性：water and saline buffer

CAS 號(hào)：not available

來(lái)源：Synthetic

純度：> 98%

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