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        1. 深圳欣博盛生物科技有限公司
          中級(jí)會(huì)員 | 第4年

          13129540117

          當(dāng)前位置:深圳欣博盛生物科技有限公司>>抗體>>內(nèi)參抗體>> InVivoMAb anti-mouse FGL-1

          InVivoMAb anti-mouse FGL-1

          參  考  價(jià)面議
          具體成交價(jià)以合同協(xié)議為準(zhǔn)

          產(chǎn)品型號(hào)

          品       牌BioxCell

          廠商性質(zhì)代理商

          所  在  地深圳市

          更新時(shí)間:2022-01-27 11:18:30瀏覽次數(shù):525次

          聯(lián)系我時(shí),請(qǐng)告知來(lái)自 化工儀器網(wǎng)
          同類優(yōu)質(zhì)產(chǎn)品更多>
          供貨周期 一個(gè)月 規(guī)格 5mg
          貨號(hào) BE0332-5MG 應(yīng)用領(lǐng)域 生物產(chǎn)業(yè)
          主要用途 科研
          The 177R4 monoclonal antibody reacts with mouse Fibrinogen-like protein 1 (FGL-1). FGL-1 is a member of the fibrinogen family of proteins. Under normal physiological conditions, FGL-1 is primarily sec

          The 177R4 monoclonal antibody reacts with mouse Fibrinogen-like protein 1 (FGL-1). FGL-1 is a member of the fibrinogen family of proteins. Under normal physiological conditions, FGL-1 is primarily secreted from hepatocytes and contributes to mitogenic and metabolic functions. FGL-1 is produced at high levels in various tumors including lung cancer and melanoma. High FGL-1 expression is associated with resistance to anti-PD-1/PD-L1 therapy and poor prognosis of cancer patients. Recently, FGL-1 has been identified as a major inhibitory ligand for LAG-3, a receptor that negatively regulates the proliferation, activation, and effector function of T cells. In murine cancer models, the 177R4 clone has been shown to block FGL-1 binding to LAG-3 resulting in boosted T cell activity and slowed tumor growth.



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