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Source

Rabbit

Applications

WB,IHC,IP,IF,ELISA

Reactivity

Human

Dilution

WB: 1:500 - 1:2000. IHC: 1:100 - 1:300. Immunoprecipitation: 2-5 ug:mg lysate. IF: 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

Storage

-20°C/1 year

Specificity

CAS Polyclonal Antibody detects endogenous levels of CAS protein.

Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen

The antiserum was produced against synthesized peptide derived from human CSE1L. AA range:1-50

Uniprot No

P55060

Alternative names

CSE1L; CAS; XPO2; Exportin-2; Exp2; Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; Importin-alpha re-exporter

Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Background

chromosome segregation 1 like(CSE1L) Homo sapiens Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012],

Other

CSE1L, Exportin-2

Mol.Wt (Da)

110417

Concentration

1 mg/ml