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          目錄:上海貝博生物科技有限公司>>Primary Antibodies>> Calreticulin rabbit pAb

          Calreticulin rabbit pAb
          • Calreticulin rabbit pAb
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          SourceRabbitApplicationsWBReactivityHuman
          • Source

            Rabbit

          • Applications

            WB

          • Reactivity

            Human, Mouse, Rat

          • Dilution

            WB 1:500-2000

          • Storage

            -20°C/1 year

          • Specificity

            This antibody detects endogenous levels of human Calreticulin

          • Source/Purification

            The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

          • Immunogen

            Recombinant Protein derived from human Calreticulin

          • Uniprot No

            P27797

          • Alternative names

            Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60)

          • Form

            Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

          • Clonality

            Polyclonal

          • Isotype

            IgG

          • Background

            calreticulin(CALR) Homo sapiens Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its

          • Other

            CALR CRTC, Calreticulin

          • Concentration

            1 mg/ml

          Product Reactivity Applications Conjugation Catalog Images

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