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DSPE-PEG2000-FA, Folate-PEG-DSPE
閱讀：492 發(fā)布時間：2018-10-25| 提 供 商 | 陜西新研博美生物科技有限公司 | 資料大小 | 5.3KB |
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DSPE-PEG2000-FA, Folate-PEG-DSPE
中文名稱：二棕櫚酰磷脂酰乙醇胺-聚乙二醇-葉酸
英文：1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethyleneglycol)]
產品外觀：淡黃色粉末
溶解度：>5mg/mL in hot water, chloroform, DMSO
PEG分子量：2000
整體分子量：3200
結構式：
產品純度：90%
產品包裝：50mg
價格：4250元
保存條件：-20℃
保存時間：1年
產品用途：用于腫瘤主動靶向
供應商：陜西新研博美生物科技有限公司
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產品描述：
DSPE-PEG-Folate (DSPE-PEG-FOL) conjugate,which can be incorporated into liposomes as a targeting ligand. Folatereceptors are cellular surface markers for numerous solid tumors and myeloidleukemias.
Folate targeted drug delivery has emergedas an alternative therapy for the treatment and imaging of many cancers andinflammatory diseases. Due to its small molecular size and high bindingaffinity for cell surface folate receptors (FR), folate conjugates have theability to deliver a variety of molecular plexes to pathologic cells withoutcausing harm to normal tissues. Complexes that have been successfully deliveredto FR expressing cells, to date, include protein toxins, immune stimulants,chemotherapeutic agents, liposomes, nanoparticles, and imaging agents. Thisreview will summarize the applications of folic acid as a targeting ligand andhighlight the various methods being developed for delivery of therapeutic andimaging agents to FR-expressing cells.