MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務(wù)。

Vitamin K1

CAS No. : 84-80-0

產(chǎn)品活性：Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

研究領(lǐng)域：Metabolic Enzyme/Protease

作用靶點：Endogenous Metabolite

結(jié)構(gòu)分類：醌類  |  萘醌類

來源：植物  |  其他科

In Vitro: Phylloquinone (Vitamin K1) is a prenylated naphthoquinone that is synthesized exclusively by plants, green algae, and some species of cyanobacteria, where it serves as a vital electron carrier in photosystem I and as an electron acceptor for the formation of protein disulfide bonds. In humans and other vertebrates, phylloquinone plays the role of a vitamin (vitamin K1) that is required for blood coagulation and bone and vascular metabolism. Phylloquinone from green leafy vegetables and vegetable oil represents the major dietary source of vitamin K for humans. Vitamin K1 treatment causes a significant antiproliferative effect and induces apoptosis in Caco-2, HT-29, and SW480 cell lines, with the involvement of the MAPK pathway. A concomitant and significant decrease in the polyamine biosynthesis occurr.

In Vivo: Subjects who increase their dietary intake of vitamin K during the follow-up had a 51% reduced risk of incident diabetes compared with subjects who decrease or does not change the amount of phylloquinone intake. Vitamin K supplementation reverses the high fat diet induced bone deterioration by modulating osteoblast and osteoclast activities and prevent bone loss in a high-fat diet-induced obese mice. Application of vitamin K1 to the skin has been used for suppression of pigmentation and resolution of bruising. The effects produced by the topical vitamin K1 shows significant healing when compared with control group in parameters such as wound contraction, epithelialization period, hydroxyproline content and tensile strength.

相關(guān)產(chǎn)品：Natural Product Library Plus  |  Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Metabolism/Protease Compound Library  |  Natural Product Library  |  FDA-Approved Drug Library  |  Human Endogenous Metabolite Compound Library  |  Drug Repurposing Compound Library  |  Anti-diabetic Compound Library  |  Lipid Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  NMPA-Approved Drug Library  |  Orally Active Compound Library  |  Traditional Chinese Medicine Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Rare Diseases Drug Library  |  Children’s Drug Library  |  Plant-Sourced Natural Product Library  |  Human Metabolite Library  |  Coagulation and Anti-coagulation Compound Library  |  Off-patent Drug Library  |  D-Valine-d₈  |  D-α-Hydroxyglutaric acid disodium  |  Nicotinamide N-oxide  |  Deoxycholic acid-d₅  |  Doxorubicin-¹³C,d₃ (TFA)  |  Palitantin  |  Estradiol hemihydrate  |  Adrenaline sulfate  |  Oleic acid-¹³C  |  Dextranase  |  H2S Donor 5a  |  Methylmalonic acid  |  Glycine, N-(aminoiminomethyl)-N-methyl-¹³C  |  Dihydroxyacetone phosphate  |  Sphingomyelin  |  (-)-Jasmonoyl-L-isoleucine  |  Octanoic acid-d₂  |  Vardenafil-d₅  |  N-Acetyllactosamine  |  D-Arabitol-¹³C  |  Imidazole  |  L-Tartaric acid diammonium  |  i-Inositol  |  Tryptophol  |  L-Aspartic acid  |  Indolelactic acid  |  6-Mercaptopurine-¹³C₂,¹⁵N  |  D-Sorbitol-d₈  |  Octanoic acid-d₃  |  Dinoprost-d₄

熱門產(chǎn)品線：重組蛋白  |  化合物庫  |  天然產(chǎn)物  |  熒光染料  |  PROTAC  |  同位素標記物  |  寡核苷酸  |  抗體  |  點擊化學(xué)

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介紹:
•   MCE (MedChemExpress) 擁有200 多種全球僅有化合物庫，我們致力于為全球科研客戶提供前沿的高品質(zhì)小分子活性化合物；
•   50,000 多種高選擇性抑制劑、激動劑涉及各熱門信號通路及疾病領(lǐng)；
•   產(chǎn)品種類涵蓋各種重組蛋白，多肽，常用試劑盒 ，更有 PROTAC、ADC 等特色產(chǎn)品，廣泛應(yīng)用于新藥研發(fā)、生命科學(xué)等科研項目；
•   提供虛擬篩選，離子通道篩選，代謝組學(xué)分析檢測分析，藥物篩選等專業(yè)技術(shù)服務(wù)；
•   設(shè)有專業(yè)的實驗中心和嚴格的質(zhì)控、驗證體系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各項質(zhì)檢報告，確保產(chǎn)品的高純度、高品質(zhì)；
•   產(chǎn)品的生物活性多經(jīng)各國客戶實驗驗證；
•   Nature, Cell, Science 等多種頂級期刊及制藥 Patent 收錄了MCE客戶的科研成果；
•   專業(yè)團隊跟蹤最新的制藥及生命科學(xué)研究進展，為您提供全球新的活性化合物；
•   與世界各大制藥公司及著名科研機構(gòu)建立了長期的合作。