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Squalamine lactate

CAS No. : 320725-47-1

產(chǎn)品活性：Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration.

研究領(lǐng)域：Anti-infection

作用靶點(diǎn)：Bacterial

結(jié)構(gòu)分類：萜類  |  三萜

In Vitro: Squalamine lactate has a more generalized effect on the cellular signaling cascade that is common to both VEGF and other growth factors. Squalamine blocks the action of VEGF and integrin expression, thereby inhibiting angiogenesis, when bound to calmodulin.

In Vivo: Squalamine is ineffective when administered intravitreally and therefore requires intravenous dosing. However, systemic dosing has yielded promising results in rats as well as humans.

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