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BOS-318

CAS No. : 2387633-15-8

產(chǎn)品活性：BOS-318 is a potent, slowly dissociating, highly selective, and cell-permeable furin inhibitor with IC₅₀ value of 1.9 nM. BOS-318 protects ENaC from subsequent activation by neutrophil elastase. BOS-318 can be used for the rsearch for CF lung disease.

研究領(lǐng)域：Others

作用靶點(diǎn)：Others

In Vitro: BOS-318 (0.001-1 μM, 72 hours) provides cytoprotection against toxicity in CuFi-1 cells induced by P aeruginosa exotoxin A (PEA).
BOS-318 (U2OS cells) to be approximately 13 times more potent against furin than PCSK5 (IC₅₀ = 25.3 nM), 24 times more potent than PCSK7 (IC₅₀ = 45.8 nM), and 110 times more potent than PCSK6 (IC₅₀ = 209.4 nM) .
BOS-318 (0.3 μM, 2 hours or 48 hours) reduces ENaC-mediated Na⁺ absorption in CF HBECs and protects against NE- and CF sputum-sol-mediated activation of the ENaC.

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