MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務(wù)。

Leritrelvir

CAS No. :

產(chǎn)品活性：Leritrelvir (RAY1216) is an orally active SARS-CoV-2 main protease slow-tight inhibitor with a K_i of 8.6 nM.

研究領(lǐng)域：Anti-infection

作用靶點：SARS-CoV

In Vitro: Leritrelvir (RAY1216) has a drug-target residence time of 104 min.
Leritrelvir is covalently attached to the catalytic Cys145 through the α-ketoamide warhead.
Leritrelvir (0-1000 nM; 72 h) shows antiviral activities against SARS-CoV-2 wild type ancestral strain and variants.

In Vivo: Leritrelvir (RAY1216 (150-600 mg/kg/day; i.g.; 5 days) effectively prolongs survival of SARS-CoV-2 infected mice.
Compound pharmacokinetics parameters in different animal species

Compound	Species	dose (mg/kg)	Cmax (nM)	Tmax (h)	AUC(0-last) (nM?h)	Cl (mL/min/kg)	Vdss (L/kg)	T1/2 (h)	oral F (%)
	Mouse	3.0 (IV)	-	-	7789	10	1.4	3.8	-
		10 (PO)	1287	2.0	5698	-	-	2.6	22
RAY1216	rat	2.0 (IV)	-	-	4505	12.5	1.1	2.2	-
		10 (PO)	916	0.9	7429	-	-	4.3	33
	cynomolgus macaque	1.0 (IV)	-	-	1157	22.5	1.0	0.9	-
		5.0 (PO)	102	1.5	458	-	-	14.9	8

C_max: the maximum observed concentration of the drug collected in bodily material from subjects in a clinical study
T_max: the time it takes to reach the maximum concentration or time to C_max
AUC: “Area Under the Curve" and represents the total exposure of the drug experienced by the subject in a clinical study
Cl: total plasma clearance
Vd_ss: Steady state volume of distribution
T_1/2: Half-time is the time it takes for half the drug concentration to be eliminated
oral (F%): Oral bioavailability

相關(guān)產(chǎn)品：Antimicrobial agent-10  |  SARS-CoV-2-IN-23  |  3CPLro-IN-1  |  SP inhibitor 1  |  rel-Zotatifin  |  Antioxidant agent-9  |  Regdanvimab  |  Silymarin  |  NHC-triphosphate tetraammonium  |  Grazoprevir potassium salt  |  Atazanavir  |  FWM-4  |  Amantadine-d₆  |  Ketotifen fumarate  |  SARS-CoV-2-IN-27  |  MMT5-14  |  Tipranavir  |  Amantadine  |  Sotrovimab  |  Antiviral agent 5  |  F8-S43-S3  |  Ritonavir-d₆  |  Fluphenazine dimaleate  |  GNF-2  |  SARS-CoV-2-IN-7  |  Mpro inhibitor N3  |  SARS-CoV-2 Mpro-IN-6  |  SARS-CoV-2-IN-32  |  Azelastine hydrochloride  |  XP-59

熱門產(chǎn)品線：重組蛋白  |  化合物庫  |  天然產(chǎn)物  |  熒光染料  |  PROTAC  |  同位素標(biāo)記物  |  寡核苷酸  |  抗體  |  點擊化學(xué)

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介紹:
•   MCE (MedChemExpress) 擁有200 多種全球僅有化合物庫，我們致力于為全球科研客戶提供前沿的高品質(zhì)小分子活性化合物；
•   50,000 多種高選擇性抑制劑、激動劑涉及各熱門信號通路及疾病領(lǐng)；
•   產(chǎn)品種類涵蓋各種重組蛋白，多肽，常用試劑盒 ，更有 PROTAC、ADC 等特色產(chǎn)品，廣泛應(yīng)用于新藥研發(fā)、生命科學(xué)等科研項目；
•   提供虛擬篩選，離子通道篩選，代謝組學(xué)分析檢測分析，藥物篩選等專業(yè)技術(shù)服務(wù)；
•   設(shè)有專業(yè)的實驗中心和嚴(yán)格的質(zhì)控、驗證體系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各項質(zhì)檢報告，確保產(chǎn)品的高純度、高品質(zhì)；
•   產(chǎn)品的生物活性多經(jīng)各國客戶實驗驗證；
•   Nature, Cell, Science 等多種頂級期刊及制藥 Patent 收錄了MCE客戶的科研成果；
•   專業(yè)團隊跟蹤最新的制藥及生命科學(xué)研究進展，為您提供全球新的活性化合物；
•   與世界各大制藥公司及著名科研機構(gòu)建立了長期的合作。