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Sparstolonin B

CAS No. : 1259330-61-4

產(chǎn)品活性：Sparstolonin B acts as a selective TLR2 and TLR4 antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities.

研究領(lǐng)域：Immunology/Inflammation  |  Anti-infection

作用靶點(diǎn)：Toll-like Receptor (TLR)  |  HIV

In Vitro: Sparstolonin B (1-20 µM; 2-4 days) inhibits cell growth and viability of neuroblastoma cells.
Sparstolonin B inhibits TLR ligand-induced cytokine expression in mouse macrophages. Sparstolonin B inhibits MyD88 recruitment to TLR4 and TLR2.
Sparstolonin B generates reactive oxygen species (ROS) in neuroblastoma cells. Sparstolonin B reduces expression of N-myc in neuroblastoma cells.

In Vivo: Sparstolonin B (100 μg/mouse; i.p.) suppresses LPS-provoked inflammation in mice.

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