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IL-2R beta/CD122 Protein, Canine (217a.a, HEK293, His)

MCE 國(guó)際站：IL-2R beta/CD122 Protein, Canine (217a.a, HEK293, His)

IL-2R beta (CD122)，一種表達(dá)于 T 淋巴細(xì)胞上的 Ⅰ 型細(xì)胞因子受體，是 IL-2 的受體。IL-2R beta 可介導(dǎo) T 細(xì)胞免疫反應(yīng)，如刺激 T 細(xì)胞增殖、激活淋巴因子激活的殺傷細(xì)胞。IL-2R beta/CD122 Protein, Canine (217a.a, HEK293, His) 是一種由 HEK293 細(xì)胞產(chǎn)生的、重組犬 IL-2R beta (217a.a, N30-P246), 其 C 末端帶有 His 標(biāo)簽。

Synonyms: IL2RB; RP5-1170K4.6; CD122; P70-75

Species: Canine

Source: HEK293

Biological Activity: Measured by its ability to inhibit the IL-15-dependent proliferation of MO7e human megakaryocytic leukemic cells. The ED₅₀ for this effect is 0.4095 μg/mL in the presence of 4 ng/mL of recombinant human IL-15, corresponding to a specific activity is 2.44×10³ units/mg.

研究背景：IL-2R beta (CD122) is a type I cytokine receptor, and belongs to Type 4 subfamily. IL-2R beta is also a key component of the IL-15 receptor. IL-2R beta is broadly expressed in spleen, blood, and lymph node, such as B and T lymphocytes.
The sequence of amino acids in IL-2R beta differs in different species.
IL-2R beta cytoplasmic domain heterodimerizes with IL-2 and leads to the activation of signaling pathways: phosphoinositol 3-kinase (PI3-K)/AKT, Ras-MAP kinase, and the JAK-STAT pathways. IL-2R beta binds IL-2 with intermediate affinity. IL-2R beta mediates IL-2 internalization and signal transduction, such as cell proliferation or differentiation. IL-2R beta interacts with IL-2 and increases the proportion of CD4+ T lymphocytes. IL-2R stimulates T cell proliferation and activating lymphokine-activated killer cells.
IL-2R beta mediates T cell immune responses, and also mediates endocytosis, as well as transducing the mitogenic signals of IL-2.

蛋白編號(hào)：NP_001273780.1 (N30-P246)

基因 ID：403439

產(chǎn)品分類：細(xì)胞因子和生長(zhǎng)因子  |  白細(xì)胞介素  |  白介素-2 受體  |  白介素-2 受體 beta  |  CD 抗原  |  NK 細(xì)胞 CD 蛋白  |  CD122/IL-2R beta

Categories：Cytokines and Growth Factors  |  Interleukin & Receptors  |  IL-2 Receptor  |  IL-2R beta  |  CD Antigens  |  NK Cell CD Proteins  |  CD122/IL-2R beta

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