目錄:MedChemExpress LLC>>信號(hào)通路>> Mitapivat | MedChemExpress
| 參考價(jià) | ￥ 946 |
| 參考價(jià) | ￥ 946 |
更新時(shí)間：2023-09-28 14:54:03瀏覽次數(shù)：179評(píng)價(jià)
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| CAS | 1260075-17-9 | 純度 | 99.85% |
|---|---|---|---|
| 分子量 | 450.55 | 分子式 | C??H??N?O?S |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL |
| 貨號(hào) | HY-12689 | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥 |
MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)。
CAS No. : 1260075-17-9
MCE 國(guó)際站：Mitapivat
產(chǎn)品活性：Mitapivat (AG-348) 是一種口服有效的丙酮酸激酶 (pyruvate kinase) 變構(gòu)激活劑。Mitapivat 在廣泛的 PKLR 基因型中增加酶活性、蛋白質(zhì)穩(wěn)定性和 ATP 水平，具有恢復(fù)丙酮酸激酶缺乏的糖酵解途徑活性的潛力。Mitapivat 可用于丙酮酸激酶缺乏癥的研究。
研究領(lǐng)域：Metabolic Enzyme/Protease
作用靶點(diǎn)：Pyruvate Kinase
In Vitro: Mitapivat (0.1 nM-100 μM; 16 h) activates WT PK-R in RBCs from healthy donors.
Mitapivat (0.01 nM-10 μM; 16 h) promotes production of ATP in RBC cells in a dose-dependent manner.
In Vivo: Mitapivat (50 mg/kg; p.o.; twice daily for 21 days) improves anemia in a mouse model for β-thalassemia.
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