目錄:MedChemExpress LLC>>信號通路>> Delamanid | MedChemExpress (MCE)
CAS | 681492-22-8 | 純度 | 99.96% |
---|---|---|---|
分子量 | 534.48 | 分子式 | C??H??F?N?O? |
供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL |
貨號 | HY-10846 | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥 |
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CAS No. : 681492-22-8
MCE 國際站:Delamanid
產(chǎn)品活性:Delamanid是一個用于耐多藥結(jié)核病的化合物,也是新的分枝桿菌細(xì)胞壁合成抑制劑。
研究領(lǐng)域:Anti-infection
作用靶點(diǎn):Bacterial | Antibiotic
In Vitro: Delamanid inhibits the synthesisi of mucolic acids, cruciala component of the cell wall of the Mycobacterium tuberculosis complex. Delamanid shows more potent antibacterial activity against drug-susceptible and drug-resistant strains of M. tuberculosis. Delamanid do not affect rifampin, pyrazinamide, and isoniazid exposure; the ethambutol AUCτ and Cmax values are about 25% higher with delamanid coadministration.
In Vivo: Delamanid (orally administration; 30 mg/kg; 5 days) results in sterile cures in a mouse model of VL.
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