目錄:MedChemExpress LLC>>信號通路>> RG7112 | MedChemExpress (MCE)
| CAS | 939981-39-2 | 純度 | 99.91% |
|---|---|---|---|
| 分子量 | 727.78 | 分子式 | C??H??Cl?N?O?S |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL |
| 貨號 | HY-10959 | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥 |
MCE 的所有產(chǎn)品僅用作科學研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務(wù)。
CAS No. : 939981-39-2
MCE 國際站：RG7112
產(chǎn)品活性：RG7112 是有效的、選擇性的、第一個用于臨床的、可口服的、可透過血腦屏障的、 MDM2-p53 抑制劑，IC50 值為 18 nM，結(jié)合到MDM2 的KD 值為 11 nM.
研究領(lǐng)域：Apoptosis | Metabolic Enzyme/Protease
作用靶點：MDM-2/p53 | E1/E2/E3 Enzyme
In Vitro: RG7112 (0-5 μM) stabilizes wild-type p53 and induces p53 signaling in cancer cells. RG7112 effectively activates p53 functions in cancer cells.
In Vivo: RG7112 (25-200 mg/kg, single oral dose) activates p53 pathway and induces apoptosis in tumor cells in vivo.
?RG7112 (100 mg/kg, gavage once per day, 5 days/week for 3 weeks ) reduces tumor growth rate and increases survival in GBM models.
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