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NVP-BEP800 返回列表頁

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品牌BPS Bioscience

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保存條件：Roomtemp

詳情介紹

保存條件：
Room temp. (continental US) or gel packs
保質(zhì)期：
Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
英文名：
NVP-BEP800
數(shù)量：
1
供應(yīng)商：
BPS Bioscience Inc.
CAS號：
/
規(guī)格：
10 mg

NVP-BEP800 is a novel, fully synthetic, orally bioavailable inhibitor that binds to the NH(2)-terminal ATP-binding pocket of Hsp90. NVP-BEP800 (also known as VER-82576) is a novel ATP-competitive HSP90β inhibitor that binds to the NH(2)-terminal ATP-binding pocket of Heat shock protein 90 (Hsp90). NVP-BEP800 induced robust antitumor responses in tumor xenograft models, including regression in the BT-474 breast cancer model. NVP-BEP800 can radiosensitise tumour cell lines of different entities through destabilisation and depletion of several Hsp90 client proteins, thus causing the depletion of S phase and G2/M arrest, increased DNA damage and repair protraction and, to some extent, apoptosis.

溫馨提示：不可用于臨床治療。