Protein phosphorylation is one of the most important post-translational modification processes. Phosphorylation is reversibly regulated by Protein Kinases (PKs) and Protein Phosphatases (PTPs). PTP1B (PTPN1) is known to catalyze dephosphorylation of insulin receptor kinases and plays a critical role in insulin signaling. The PTP1B (Catalytic Domain) Colorimetric Assay Kit is designed to measure PTP1B activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps. The PTP1B assay kit comes in a convenient 96-well format, with purified PTP1B enzyme, colorimetric substrate, and PTP assay buffer for 100 enzyme reactions. The PTP1B (Catalytic Domain) Colorimetric Assay Kit is optimized for both continuous and end-point assay formats.

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