Tamapin 

Selective blocker of SK2 (K_Ca2.2) channels

SK2 (K_Ca2.2)通道選擇性阻斷劑

Tamapin is a peptide toxin isolated from the venom of the Indian red scorpion Mesobuthus Tamulus.  is amidated at its C-terminal tyrosine residue.  binds to small conductance Ca²⁺-activated K⁺ channels (SK channels) with high affinity and inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus as well as in cell lines expressing distinct SK channel subunits. Contrary to  Apamin or  Leiurotoxin-1 (Scyllatoxin), is an excellent toxin to discriminate among SK channel subtypes because it presents different affinities for SK1 (42 nM), SK2 (24 pM) and SK3 (1.7 nM) channels. This toxin is also the most potent SK2 channel blocker characterized so far (IC₅₀ for SK2 channels = 24 pM).

技術(shù)資料

氨基酸序列：

Ala-Phe-Cys³-Asn-Leu-Arg-Arg-Cys⁸-Glu-Leu-Ser-Cys¹²-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys²¹ -Ile-Gly-Glu-Glu-Cys²⁶-Lys -Cys²⁸-Val-Pro-Tyr-NH₂ 

二硫鍵： Cys³-Cys²¹; Cys⁸-Cys²⁶; Cys¹²-Cys²⁸ 

長(zhǎng)度（aa）： 31  

分子式：C₁₄₆H₂₃₇N₄₄O₄₁S₆  

分子量： 3459.00 Da  

外觀：White lyophilized solid  

可溶性： water and saline buffer  

CAS號(hào)： not available  

來(lái)源：Synthetic 

純度：> 97 %

產(chǎn)品信息